Juvenile hormone signaling promotes ovulation and maintains egg shape by inducing expression of extracellular matrix genes

Wei Luo, Suning Liu, Wenqiang Zhang, Liu Yang, Jianhua Huang, Shutang Zhou, Qili Feng, Subba Reddy Palli, Jian Wang, Siegfried Roth, Sheng Li

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

It is well documented that the juvenile hormone (JH) can function as a gonadotropic hormone that stimulates vitellogenesis by activating the production and uptake of vitellogenin in insects. Here, we describe a phenotype associated with mutations in the Drosophila JH receptor genes, Met and Gce: The accumulation of mature eggs with reduced egg length in the ovary. JH signaling is mainly activated in ovarian muscle cells and induces laminin gene expression in these cells. Meanwhile, JH signaling induces collagen IV gene expression in the adult fat body, from which collagen IV is secreted and deposited onto the ovarian muscles. Laminin locally and collagen IV remotely contribute to the assembly of ovarian muscle extracellular matrix (ECM); moreover, the ECM components are indispensable for ovarian muscle contraction. Furthermore, ovarian muscle contraction externally generates a mechanical force to promote ovulation and maintain egg shape. This work reveals an important mechanism for JHregulated insect reproduction.

Original languageEnglish
Article numbere2104461118
JournalProceedings of the National Academy of Sciences of the United States of America
Volume118
Issue number39
DOIs
StatePublished - Sep 28 2021

Bibliographical note

Publisher Copyright:
© 2021 National Academy of Sciences. All rights reserved.

Keywords

  • Collagen IV
  • Egg chamber elongation
  • Laminin
  • Ovarian contraction
  • Visceral muscle

ASJC Scopus subject areas

  • General

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