k opioids as potential treatments for stimulants dependence

Thomas E. Prisinzano; Kevin Tidgewell; Wayne W. Harding

doi:10.1208/aapsj070361

k opioids as potential treatments for stimulants dependence

Thomas E. Prisinzano, Kevin Tidgewell, Wayne W. Harding

Research output: Contribution to journal › Review article › peer-review

61 Scopus citations

Abstract

Stimulant abuse is a major problem in the United States and the development of pharmacological treatments for stimulant abuse remains an important therapeutic goal. Classically, the "dopamine hypothesis" has been used to explain the development of addiction and dependence of stimulants. This hypothesis involves the direct increase of dopamine as the major factor mediating the abuse effects. Therefore, most treatments have focused on directly influencing the dopamine system. Another approach, which has been explored for potential treatments of stimulant abuse, is the use of K opioid agonists. The K receptor is known to be involved, via indirect effects, in synaptic dopamine levels. This review covers several classes Of K opioid ligands that have been explored for this purpose.

Original language	English
Article number	61
Journal	AAPS Journal
Volume	7
Issue number	3
DOIs	https://doi.org/10.1208/aapsj070361
State	Published - Oct 19 2005

Bibliographical note

Funding Information:
The authors wish to thank the College of Pharmacy and the Biological Sciences Funding Program of the University of Iowa for financial support of our research program.

Funding

The authors wish to thank the College of Pharmacy and the Biological Sciences Funding Program of the University of Iowa for financial support of our research program.

Funders	Funder number
University of Northern Iowa

Keywords

Kappa
Opioid
Self-administration
Stimulant

ASJC Scopus subject areas

Pharmaceutical Science

Access to Document

10.1208/aapsj070361

Cite this

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title = "k opioids as potential treatments for stimulants dependence",

abstract = "Stimulant abuse is a major problem in the United States and the development of pharmacological treatments for stimulant abuse remains an important therapeutic goal. Classically, the {"}dopamine hypothesis{"} has been used to explain the development of addiction and dependence of stimulants. This hypothesis involves the direct increase of dopamine as the major factor mediating the abuse effects. Therefore, most treatments have focused on directly influencing the dopamine system. Another approach, which has been explored for potential treatments of stimulant abuse, is the use of K opioid agonists. The K receptor is known to be involved, via indirect effects, in synaptic dopamine levels. This review covers several classes Of K opioid ligands that have been explored for this purpose.",

keywords = "Kappa, Opioid, Self-administration, Stimulant",

author = "Prisinzano, {Thomas E.} and Kevin Tidgewell and Harding, {Wayne W.}",

note = "Funding Information: The authors wish to thank the College of Pharmacy and the Biological Sciences Funding Program of the University of Iowa for financial support of our research program.",

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month = oct,

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doi = "10.1208/aapsj070361",

language = "English",

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TY - JOUR

T1 - k opioids as potential treatments for stimulants dependence

AU - Prisinzano, Thomas E.

AU - Tidgewell, Kevin

AU - Harding, Wayne W.

N1 - Funding Information: The authors wish to thank the College of Pharmacy and the Biological Sciences Funding Program of the University of Iowa for financial support of our research program.

PY - 2005/10/19

Y1 - 2005/10/19

N2 - Stimulant abuse is a major problem in the United States and the development of pharmacological treatments for stimulant abuse remains an important therapeutic goal. Classically, the "dopamine hypothesis" has been used to explain the development of addiction and dependence of stimulants. This hypothesis involves the direct increase of dopamine as the major factor mediating the abuse effects. Therefore, most treatments have focused on directly influencing the dopamine system. Another approach, which has been explored for potential treatments of stimulant abuse, is the use of K opioid agonists. The K receptor is known to be involved, via indirect effects, in synaptic dopamine levels. This review covers several classes Of K opioid ligands that have been explored for this purpose.

AB - Stimulant abuse is a major problem in the United States and the development of pharmacological treatments for stimulant abuse remains an important therapeutic goal. Classically, the "dopamine hypothesis" has been used to explain the development of addiction and dependence of stimulants. This hypothesis involves the direct increase of dopamine as the major factor mediating the abuse effects. Therefore, most treatments have focused on directly influencing the dopamine system. Another approach, which has been explored for potential treatments of stimulant abuse, is the use of K opioid agonists. The K receptor is known to be involved, via indirect effects, in synaptic dopamine levels. This review covers several classes Of K opioid ligands that have been explored for this purpose.

KW - Kappa

KW - Opioid

KW - Self-administration

KW - Stimulant

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DO - 10.1208/aapsj070361

M3 - Review article

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JO - AAPS Journal

JF - AAPS Journal

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ER -

k opioids as potential treatments for stimulants dependence

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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