Abstract
This study utilized Timm histochemistry and immunocytochemistry to determine the prolonged effects of kainic acid on the distribution of dynorphin- and enkephalin-containing mossy fibers in the rat dentate gyrus at progressive time points following kainic acid injection. Beginning 1-2 weeks after kainic acid administration, a progressive increase in the distribution and intensity of staining for supragranular zinc, dynorphin and enkephalin was observed in the dentate gyrus. The kainic acid-induced sprouting of mossy fibers containing dynorphin and enkephalin strongly resembles the pattern observed in the dentate gyrus of humans with temporal lobe epilepsy.
Original language | English |
---|---|
Pages (from-to) | 318-323 |
Number of pages | 6 |
Journal | Brain Research |
Volume | 747 |
Issue number | 2 |
DOIs | |
State | Published - Feb 7 1997 |
Keywords
- epilepsy
- hippocampal plasticity
- immunocytochemistry
- opioid peptide
- recurrent seizure
ASJC Scopus subject areas
- General Neuroscience
- Molecular Biology
- Clinical Neurology
- Developmental Biology