Kainic acid-induced sprouting of dynorphin- and enkephalin- containing mossy fibers in the dentate gyrus of the rat hippocampus

Jeffrey N. Simpson, Wan Qin Zhang, Guoying Bing, Jau Shyong Hong

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

This study utilized Timm histochemistry and immunocytochemistry to determine the prolonged effects of kainic acid on the distribution of dynorphin- and enkephalin-containing mossy fibers in the rat dentate gyrus at progressive time points following kainic acid injection. Beginning 1-2 weeks after kainic acid administration, a progressive increase in the distribution and intensity of staining for supragranular zinc, dynorphin and enkephalin was observed in the dentate gyrus. The kainic acid-induced sprouting of mossy fibers containing dynorphin and enkephalin strongly resembles the pattern observed in the dentate gyrus of humans with temporal lobe epilepsy.

Original languageEnglish
Pages (from-to)318-323
Number of pages6
JournalBrain Research
Volume747
Issue number2
DOIs
StatePublished - Feb 7 1997

Keywords

  • epilepsy
  • hippocampal plasticity
  • immunocytochemistry
  • opioid peptide
  • recurrent seizure

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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