Keeping an eye on SOXC proteins

Lakshmi Pillai-Kastoori, Wen Wen, Ann C. Morris

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


The formation of a mature, functional eye requires a complex series of cell proliferation, migration, induction among different germinal layers, and cell differentiation. These processes are regulated by extracellular cues such as the Wnt/BMP/Hh/Fgf signaling pathways, as well as cell intrinsic transcription factors that specify cell fate. In this review article, we provide an overview of stages of embryonic eye morphogenesis, extrinsic and intrinsic factors that are required for each stage, and pediatric ocular diseases that are associated with defective eye development. In addition, we focus on recent findings about the roles of the SOXC proteins in regulating vertebrate ocular development and implicating SOXC mutations in human ocular malformations.

Original languageEnglish
Pages (from-to)367-376
Number of pages10
JournalDevelopmental Dynamics
Issue number3
StatePublished - Mar 1 2015

Bibliographical note

Publisher Copyright:
© 2014 Wiley Periodicals, Inc.


  • Eye development
  • Ocular morphogenesis
  • SOXC

ASJC Scopus subject areas

  • Developmental Biology


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