Keratinocyte growth factor accelerates wound closure of airway epithelium during cyclic strain

C. M. Waters, U. Savla

Research output: Contribution to conferencePaperpeer-review

Abstract

Wound closure was investigated using primary cultures of cat tracheal epithelium (CTE), normal human bronchial airway epithelial cells (NHBE), and a cell line of human airway epithelial cells (Calu 3). CTE wound closure in the periphery and in the center of unstretched wells was identical, but wound closure in the periphery and in the center of wells subjected to cyclic strain was inhibited. Similar results were obtained for NHBE and Calu 3 cells. Cyclic elongation and cyclic compression inhibited overall epithelial wound closure in vitro. Furthermore, keratinocyte growth factor significantly accelerated wound closure and overcame the inhibitory effects of cyclic strain.

Original languageEnglish
Pages99
Number of pages1
StatePublished - 1998
EventProceedings of the 1998 17th Southern Biomedical Engineering Conference - San Antonio, TX, USA
Duration: Feb 6 1998Feb 8 1998

Conference

ConferenceProceedings of the 1998 17th Southern Biomedical Engineering Conference
CitySan Antonio, TX, USA
Period2/6/982/8/98

ASJC Scopus subject areas

  • Engineering (all)

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