Abstract
Koch's postulates were formulated in the late nineteenth century as guidelines for establishing that microbes cause specific diseases. Because the rules were developed for living agents - particularly bacteria - their applicability to inanimate pathogens such as viruses and infectious proteins has been problematic. The unorthodox mechanism by which prion diseases are transmitted, involving specific physicochemical characteristics of the protein as well as susceptibility traits of the host, has made these disorders refractory to analysis within the context of the original Koch's postulates. In addition, evidence is accumulating that other proteopathies, such as AA amyloidosis, apolipoprotein AII amyloidosis, and cerebral Aβ amyloidosis, can be induced in vulnerable recipients by cognate proteinaceous agents. In light of the salient differences in the mode of disease-transmission by microbes and proteins, we propose modifications of Koch's postulates that will specifically accommodate presumed infectious proteins.
| Original language | English |
|---|---|
| Pages (from-to) | 1-4 |
| Number of pages | 4 |
| Journal | Acta Neuropathologica |
| Volume | 112 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jul 2006 |
Bibliographical note
Funding Information:Acknowledgments We thank Ingo Autenrieth, John Hardy, Jens Pahnke, Rebecca Rosen, Margaret Walker and Rolf Warzok for helpful discussions. This work was supported by grants from the WoodruV Foundation, NIH (RR-00165), by the Sanders-Brown Center on Aging and Chandler Medical Center of the University of Kentucky, and by the Alzheimer’s Association.
Funding
Acknowledgments We thank Ingo Autenrieth, John Hardy, Jens Pahnke, Rebecca Rosen, Margaret Walker and Rolf Warzok for helpful discussions. This work was supported by grants from the WoodruV Foundation, NIH (RR-00165), by the Sanders-Brown Center on Aging and Chandler Medical Center of the University of Kentucky, and by the Alzheimer’s Association.
| Funders | Funder number |
|---|---|
| College of Medicine and Chancellor’s Office Chandler Medical Center | |
| Sanders-Brown Center on Aging | |
| WoodruV Foundation | |
| National Institutes of Health (NIH) | |
| National Center for Research Resources | P51RR000165 |
| Alzheimer's Association | |
| University of Kentucky |
Keywords
- Alzheimer's disease
- Amyloid
- Apolipoprotein AII
- Conformational disease
- Prion
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Clinical Neurology
- Cellular and Molecular Neuroscience