Abstract
L-type calcium channels (LTCC) impact the function of nearly all excitable cells. The classical LTCC function is to mediate trans-sarcolemmal Ca2+ flux. This review focuses on the contribution of a mobile segment of the LTCC that regulates ion channel function, and also serves as a regulator of transcription in the nucleus. Specifically we highlight recent work demonstrating an auto-feedback regulatory pathway whereby the LTCC transcription factor regulates the LTCC. Also discussed is acute and long-term regulation of function by the LTCC-transcription regulator.
Original language | English |
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Pages (from-to) | 306-313 |
Number of pages | 8 |
Journal | Cell Calcium |
Volume | 49 |
Issue number | 5 |
DOIs | |
State | Published - May 2011 |
Bibliographical note
Funding Information:We are grateful for the many insightful discussions with Dr Douglas Andres. This work was supported by NIH HL074091 (JS), and an NIH Interdisciplinary Cardiovascular Sciences Training Grant HL-072734 (SMC).
Keywords
- Calcium
- Calcium current
- Cardiac calcium channel
- Cardiac myocyte
- Gene regulation
- L-type calcium channel
ASJC Scopus subject areas
- Physiology
- Molecular Biology
- Cell Biology