L-type calcium channel auto-regulation of transcription

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations

Abstract

L-type calcium channels (LTCC) impact the function of nearly all excitable cells. The classical LTCC function is to mediate trans-sarcolemmal Ca2+ flux. This review focuses on the contribution of a mobile segment of the LTCC that regulates ion channel function, and also serves as a regulator of transcription in the nucleus. Specifically we highlight recent work demonstrating an auto-feedback regulatory pathway whereby the LTCC transcription factor regulates the LTCC. Also discussed is acute and long-term regulation of function by the LTCC-transcription regulator.

Original languageEnglish
Pages (from-to)306-313
Number of pages8
JournalCell Calcium
Volume49
Issue number5
DOIs
StatePublished - May 2011

Bibliographical note

Funding Information:
We are grateful for the many insightful discussions with Dr Douglas Andres. This work was supported by NIH HL074091 (JS), and an NIH Interdisciplinary Cardiovascular Sciences Training Grant HL-072734 (SMC).

Keywords

  • Calcium
  • Calcium current
  • Cardiac calcium channel
  • Cardiac myocyte
  • Gene regulation
  • L-type calcium channel

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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