Lack of association between polymorphic variations in the α3 subunit GABA receptor gene (GABRA3) and suicide attempts

Enrique Baca-Garcia; Concepción Vaquero; Carmen Diaz-Sastre; Luis Jimenez-Treviño; Jeronimo Saiz-Ruiz; José Fernández-Piqueras; Jose De Leon

doi:10.1016/j.pnpbp.2003.11.004

Lack of association between polymorphic variations in the α3 subunit GABA receptor gene (GABRA3) and suicide attempts

Enrique Baca-Garcia, Concepción Vaquero, Carmen Diaz-Sastre, Luis Jimenez-Treviño, Jeronimo Saiz-Ruiz, José Fernández-Piqueras, Jose De Leon

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

This is the first case-control study exploring the association between suicide attempts and the polymorphic variations of the α3 subunit γ-aminobutyric acid (GABA) receptor gene (GABRA3) located in chromosome X. In a Spanish general hospital, 184 suicide attempters (127 women and 57 men) and 275 control blood donors (109 women and 166 men) were recruited. The four frequent variants (A1, A2, A3 and A4) of GABRA3 were studied. There were no significant differences in the total or by-gender frequencies of the four alleles. In females, there were no significant differences in the genotypes. This study can rule out even small size effects in the total sample and suggests a lack of association between GABRA3 polymorphism and suicide attempt, in the Spanish population.

Original language	English
Pages (from-to)	409-412
Number of pages	4
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Volume	28
Issue number	2
DOIs	https://doi.org/10.1016/j.pnpbp.2003.11.004
State	Published - Mar 2004

Bibliographical note

Funding Information:
This article was partly supported by a 2001 National Alliance for Research on Schizophrenia and Affective Disorders (NARSAD) Young Investigator Award and a grant from the Spanish Health Ministry (FIS 00/317). The authors thank Margaret T. Susce, R.N., M.L.T. for editorial assistance.

Funding

This article was partly supported by a 2001 National Alliance for Research on Schizophrenia and Affective Disorders (NARSAD) Young Investigator Award and a grant from the Spanish Health Ministry (FIS 00/317). The authors thank Margaret T. Susce, R.N., M.L.T. for editorial assistance.

Funders	Funder number
National Alliance for Research on Schizophrenia and Affective Disorders
Spanish Ministry of Health	FIS 00/317

Keywords

Case-control study
GABA
GABRA3
Genetics
Suicide
Suicide attempt

ASJC Scopus subject areas

Pharmacology
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.pnpbp.2003.11.004

Cite this

Baca-Garcia, E., Vaquero, C., Diaz-Sastre, C., Jimenez-Treviño, L., Saiz-Ruiz, J., Fernández-Piqueras, J., & De Leon, J. (2004). Lack of association between polymorphic variations in the α3 subunit GABA receptor gene (GABRA3) and suicide attempts. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 28(2), 409-412. https://doi.org/10.1016/j.pnpbp.2003.11.004

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abstract = "This is the first case-control study exploring the association between suicide attempts and the polymorphic variations of the α3 subunit γ-aminobutyric acid (GABA) receptor gene (GABRA3) located in chromosome X. In a Spanish general hospital, 184 suicide attempters (127 women and 57 men) and 275 control blood donors (109 women and 166 men) were recruited. The four frequent variants (A1, A2, A3 and A4) of GABRA3 were studied. There were no significant differences in the total or by-gender frequencies of the four alleles. In females, there were no significant differences in the genotypes. This study can rule out even small size effects in the total sample and suggests a lack of association between GABRA3 polymorphism and suicide attempt, in the Spanish population.",

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Baca-Garcia, E, Vaquero, C, Diaz-Sastre, C, Jimenez-Treviño, L, Saiz-Ruiz, J, Fernández-Piqueras, J & De Leon, J 2004, 'Lack of association between polymorphic variations in the α3 subunit GABA receptor gene (GABRA3) and suicide attempts', Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 28, no. 2, pp. 409-412. https://doi.org/10.1016/j.pnpbp.2003.11.004

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AU - Jimenez-Treviño, Luis

AU - Saiz-Ruiz, Jeronimo

AU - Fernández-Piqueras, José

AU - De Leon, Jose

N1 - Funding Information: This article was partly supported by a 2001 National Alliance for Research on Schizophrenia and Affective Disorders (NARSAD) Young Investigator Award and a grant from the Spanish Health Ministry (FIS 00/317). The authors thank Margaret T. Susce, R.N., M.L.T. for editorial assistance.

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Lack of association between polymorphic variations in the α3 subunit GABA receptor gene (GABRA3) and suicide attempts

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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