Lack of association of hepatic lipase polymorphisms with late-onset Alzheimer's disease

Haiyan Zhu; Jennie W. Taylor; David A. Bennett; Steven G. Younkin; Steven Estus

doi:10.1016/j.neurobiolaging.2006.11.015

Lack of association of hepatic lipase polymorphisms with late-onset Alzheimer's disease

Haiyan Zhu, Jennie W. Taylor, David A. Bennett, Steven G. Younkin, Steven Estus

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Several polymorphisms in hepatic lipase (LIPC) are similar to apoE4 because they associate with cholesterol concentrations and, for rs6084, coronary artery disease (CAD). Since apoE4 is also a primary genetic risk factor for late-onset Alzheimer's disease (LOAD), LIPC single nucleotide polymorphisms (SNP)s represent excellent candidates for LOAD association studies. Because this issue has not been addressed previously, we evaluated LIPC SNP association with LOAD. In a population from the Religious Orders Study (ROS), rs6084 was nominally associated with LOAD odds (p = 0.015 by χ² test). However, this association was not confirmed in two subsequent series based at the University of Kentucky (UKY, p = 0.15) or the Mayo Clinic in Jacksonville (MCJ, p = 0.97). Hence, rs6084 is not consistently associated with LOAD.

Original language	English
Pages (from-to)	793-794
Number of pages	2
Journal	Neurobiology of Aging
Volume	29
Issue number	5
DOIs	https://doi.org/10.1016/j.neurobiolaging.2006.11.015
State	Published - May 2008

Keywords

Alzheimer's disease
Apolipoprotein E
Genetics
Hepatic lipase

ASJC Scopus subject areas

Clinical Neurology
Geriatrics and Gerontology
Aging
General Neuroscience
Developmental Biology

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10.1016/j.neurobiolaging.2006.11.015

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title = "Lack of association of hepatic lipase polymorphisms with late-onset Alzheimer's disease",

abstract = "Several polymorphisms in hepatic lipase (LIPC) are similar to apoE4 because they associate with cholesterol concentrations and, for rs6084, coronary artery disease (CAD). Since apoE4 is also a primary genetic risk factor for late-onset Alzheimer's disease (LOAD), LIPC single nucleotide polymorphisms (SNP)s represent excellent candidates for LOAD association studies. Because this issue has not been addressed previously, we evaluated LIPC SNP association with LOAD. In a population from the Religious Orders Study (ROS), rs6084 was nominally associated with LOAD odds (p = 0.015 by χ2 test). However, this association was not confirmed in two subsequent series based at the University of Kentucky (UKY, p = 0.15) or the Mayo Clinic in Jacksonville (MCJ, p = 0.97). Hence, rs6084 is not consistently associated with LOAD.",

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AU - Zhu, Haiyan

AU - Taylor, Jennie W.

AU - Bennett, David A.

AU - Younkin, Steven G.

AU - Estus, Steven

PY - 2008/5

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N2 - Several polymorphisms in hepatic lipase (LIPC) are similar to apoE4 because they associate with cholesterol concentrations and, for rs6084, coronary artery disease (CAD). Since apoE4 is also a primary genetic risk factor for late-onset Alzheimer's disease (LOAD), LIPC single nucleotide polymorphisms (SNP)s represent excellent candidates for LOAD association studies. Because this issue has not been addressed previously, we evaluated LIPC SNP association with LOAD. In a population from the Religious Orders Study (ROS), rs6084 was nominally associated with LOAD odds (p = 0.015 by χ2 test). However, this association was not confirmed in two subsequent series based at the University of Kentucky (UKY, p = 0.15) or the Mayo Clinic in Jacksonville (MCJ, p = 0.97). Hence, rs6084 is not consistently associated with LOAD.

AB - Several polymorphisms in hepatic lipase (LIPC) are similar to apoE4 because they associate with cholesterol concentrations and, for rs6084, coronary artery disease (CAD). Since apoE4 is also a primary genetic risk factor for late-onset Alzheimer's disease (LOAD), LIPC single nucleotide polymorphisms (SNP)s represent excellent candidates for LOAD association studies. Because this issue has not been addressed previously, we evaluated LIPC SNP association with LOAD. In a population from the Religious Orders Study (ROS), rs6084 was nominally associated with LOAD odds (p = 0.015 by χ2 test). However, this association was not confirmed in two subsequent series based at the University of Kentucky (UKY, p = 0.15) or the Mayo Clinic in Jacksonville (MCJ, p = 0.97). Hence, rs6084 is not consistently associated with LOAD.

KW - Alzheimer's disease

KW - Apolipoprotein E

KW - Genetics

KW - Hepatic lipase

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Lack of association of hepatic lipase polymorphisms with late-onset Alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

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