Lack of association of hepatic lipase polymorphisms with late-onset Alzheimer's disease

Haiyan Zhu, Jennie W. Taylor, David A. Bennett, Steven G. Younkin, Steven Estus

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Several polymorphisms in hepatic lipase (LIPC) are similar to apoE4 because they associate with cholesterol concentrations and, for rs6084, coronary artery disease (CAD). Since apoE4 is also a primary genetic risk factor for late-onset Alzheimer's disease (LOAD), LIPC single nucleotide polymorphisms (SNP)s represent excellent candidates for LOAD association studies. Because this issue has not been addressed previously, we evaluated LIPC SNP association with LOAD. In a population from the Religious Orders Study (ROS), rs6084 was nominally associated with LOAD odds (p = 0.015 by χ2 test). However, this association was not confirmed in two subsequent series based at the University of Kentucky (UKY, p = 0.15) or the Mayo Clinic in Jacksonville (MCJ, p = 0.97). Hence, rs6084 is not consistently associated with LOAD.

Original languageEnglish
Pages (from-to)793-794
Number of pages2
JournalNeurobiology of Aging
Issue number5
StatePublished - May 2008


  • Alzheimer's disease
  • Apolipoprotein E
  • Genetics
  • Hepatic lipase

ASJC Scopus subject areas

  • Clinical Neurology
  • Geriatrics and Gerontology
  • Aging
  • General Neuroscience
  • Developmental Biology


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