Lack of effect of entorhinal kindling on l-[3H]glutamic acid presynaptic uptake and postsynaptic binding in hippocampus

John T. Slevin; Lindley P. Ferrara

doi:10.1016/0014-4886(85)90264-X

Lack of effect of entorhinal kindling on l-[³H]glutamic acid presynaptic uptake and postsynaptic binding in hippocampus

John T. Slevin, Lindley P. Ferrara

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Sodium-independent l-[³H]glutamic acid binding and sodium-dependent l-[³H]glutamic acid high affinity uptake were measured in hippocampal membranes of rats administered electroshock seizures or kindled to class 5 seizures by entorhinal cortical stimulation. There were no differences in these glutamatergic synaptic markers among electroshocked, kindled, or surgical control animals. Entorhinal kindling is not a reflection of activity-regulated facilitation of perforant path glutamatergic neurotransmission.

Original language	English
Pages (from-to)	48-58
Number of pages	11
Journal	Experimental Neurology
Volume	89
Issue number	1
DOIs	https://doi.org/10.1016/0014-4886(85)90264-X
State	Published - Jul 1985

Bibliographical note

Funding Information:
Abbreviations: LTP-long-term potentiation. ’ This work was supported in part by the Veterans Administration and the National Institutes of Health (TIDA NSO0732 to J.T.S.). We thank Patricia Lee for preparation of the manuscript. Please send reprint requests to J.T.S.

ASJC Scopus subject areas

Neurology
Developmental Neuroscience

Access to Document

10.1016/0014-4886(85)90264-X

Cite this

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abstract = "Sodium-independent l-[3H]glutamic acid binding and sodium-dependent l-[3H]glutamic acid high affinity uptake were measured in hippocampal membranes of rats administered electroshock seizures or kindled to class 5 seizures by entorhinal cortical stimulation. There were no differences in these glutamatergic synaptic markers among electroshocked, kindled, or surgical control animals. Entorhinal kindling is not a reflection of activity-regulated facilitation of perforant path glutamatergic neurotransmission.",

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