Lack of genetic association of cholesteryl ester transfer protein polymorphisms with late onset Alzheimers disease

Haiyan Zhu; Rangaraj K. Gopalraj; Jeremiah F. Kelly; David A. Bennett; Steven Estus

doi:10.1016/j.neulet.2005.01.078

Lack of genetic association of cholesteryl ester transfer protein polymorphisms with late onset Alzheimers disease

Haiyan Zhu, Rangaraj K. Gopalraj, Jeremiah F. Kelly, David A. Bennett, Steven Estus

Physiology

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Dysregulation of cholesterol homeostasis may be associated with the pathogenesis of coronary artery disease (CAD) and Alzheimers disease (AD). Recently, several single nucleotide polymorphisms (SNPs) in cholesteryl ester transfer protein (CETP) were associated with altered plasma CETP concentrations, cholesterol concentrations and CAD. Hence, these CETP SNPs represent excellent candidates for evaluating association with AD. To date, one study has evaluated the association between a single CETP SNP and AD. In this study, we examined three CETP SNPs to evaluate the genetic association of CETP with late onset AD on two study cohorts: the Religious Orders Study (ROS) series, including 85 AD and 70 non-AD individuals, and the University of Kentucky (UKY) series, including 78 AD and 84 non-AD individuals. Significant association between CETP genotypes or haplotypes and late onset AD was not detected in these two study cohorts. Moreover, the CETP genotypes and haplotypes were not significantly associated with AD when the populations were stratified for the presence or absence of apolipoprotein E4 (apoE4). In summary, CETP genetic variants were not associated with AD in two series.

Original language	English
Pages (from-to)	36-41
Number of pages	6
Journal	Neuroscience Letters
Volume	381
Issue number	1-2
DOIs	https://doi.org/10.1016/j.neulet.2005.01.078
State	Published - Jun 10 2005

Bibliographical note

Funding Information:
The authors thank the UKY AD Research Center including William Markesbery and members of the Estus laboratory for helpful discussion. They also thank Joseph Pulliam for isolating the DNA from the ROS series. We thank the participants in the Religious Orders Study, the BRAiNS Study, and the patients at the UKY AD Center. This project was funded by the NIH (R01AG21545, 2P50AG05144, R01AG21362, P30AG10161, and R01AG15819).

Keywords

Alzheimers disease
Apolipoprotein E
Cholesteryl ester transfer protein
Genetic association
Haplotype
Polymorphism

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1016/j.neulet.2005.01.078

Cite this

@article{7c1924a511e54d8b8364fa18f73e5251,

title = "Lack of genetic association of cholesteryl ester transfer protein polymorphisms with late onset Alzheimers disease",

abstract = "Dysregulation of cholesterol homeostasis may be associated with the pathogenesis of coronary artery disease (CAD) and Alzheimers disease (AD). Recently, several single nucleotide polymorphisms (SNPs) in cholesteryl ester transfer protein (CETP) were associated with altered plasma CETP concentrations, cholesterol concentrations and CAD. Hence, these CETP SNPs represent excellent candidates for evaluating association with AD. To date, one study has evaluated the association between a single CETP SNP and AD. In this study, we examined three CETP SNPs to evaluate the genetic association of CETP with late onset AD on two study cohorts: the Religious Orders Study (ROS) series, including 85 AD and 70 non-AD individuals, and the University of Kentucky (UKY) series, including 78 AD and 84 non-AD individuals. Significant association between CETP genotypes or haplotypes and late onset AD was not detected in these two study cohorts. Moreover, the CETP genotypes and haplotypes were not significantly associated with AD when the populations were stratified for the presence or absence of apolipoprotein E4 (apoE4). In summary, CETP genetic variants were not associated with AD in two series.",

keywords = "Alzheimers disease, Apolipoprotein E, Cholesteryl ester transfer protein, Genetic association, Haplotype, Polymorphism",

author = "Haiyan Zhu and Gopalraj, {Rangaraj K.} and Kelly, {Jeremiah F.} and Bennett, {David A.} and Steven Estus",

note = "Funding Information: The authors thank the UKY AD Research Center including William Markesbery and members of the Estus laboratory for helpful discussion. They also thank Joseph Pulliam for isolating the DNA from the ROS series. We thank the participants in the Religious Orders Study, the BRAiNS Study, and the patients at the UKY AD Center. This project was funded by the NIH (R01AG21545, 2P50AG05144, R01AG21362, P30AG10161, and R01AG15819).",

year = "2005",

month = jun,

day = "10",

doi = "10.1016/j.neulet.2005.01.078",

language = "English",

volume = "381",

pages = "36--41",

number = "1-2",

}

TY - JOUR

T1 - Lack of genetic association of cholesteryl ester transfer protein polymorphisms with late onset Alzheimers disease

AU - Zhu, Haiyan

AU - Gopalraj, Rangaraj K.

AU - Kelly, Jeremiah F.

AU - Bennett, David A.

AU - Estus, Steven

N1 - Funding Information: The authors thank the UKY AD Research Center including William Markesbery and members of the Estus laboratory for helpful discussion. They also thank Joseph Pulliam for isolating the DNA from the ROS series. We thank the participants in the Religious Orders Study, the BRAiNS Study, and the patients at the UKY AD Center. This project was funded by the NIH (R01AG21545, 2P50AG05144, R01AG21362, P30AG10161, and R01AG15819).

PY - 2005/6/10

Y1 - 2005/6/10

N2 - Dysregulation of cholesterol homeostasis may be associated with the pathogenesis of coronary artery disease (CAD) and Alzheimers disease (AD). Recently, several single nucleotide polymorphisms (SNPs) in cholesteryl ester transfer protein (CETP) were associated with altered plasma CETP concentrations, cholesterol concentrations and CAD. Hence, these CETP SNPs represent excellent candidates for evaluating association with AD. To date, one study has evaluated the association between a single CETP SNP and AD. In this study, we examined three CETP SNPs to evaluate the genetic association of CETP with late onset AD on two study cohorts: the Religious Orders Study (ROS) series, including 85 AD and 70 non-AD individuals, and the University of Kentucky (UKY) series, including 78 AD and 84 non-AD individuals. Significant association between CETP genotypes or haplotypes and late onset AD was not detected in these two study cohorts. Moreover, the CETP genotypes and haplotypes were not significantly associated with AD when the populations were stratified for the presence or absence of apolipoprotein E4 (apoE4). In summary, CETP genetic variants were not associated with AD in two series.

AB - Dysregulation of cholesterol homeostasis may be associated with the pathogenesis of coronary artery disease (CAD) and Alzheimers disease (AD). Recently, several single nucleotide polymorphisms (SNPs) in cholesteryl ester transfer protein (CETP) were associated with altered plasma CETP concentrations, cholesterol concentrations and CAD. Hence, these CETP SNPs represent excellent candidates for evaluating association with AD. To date, one study has evaluated the association between a single CETP SNP and AD. In this study, we examined three CETP SNPs to evaluate the genetic association of CETP with late onset AD on two study cohorts: the Religious Orders Study (ROS) series, including 85 AD and 70 non-AD individuals, and the University of Kentucky (UKY) series, including 78 AD and 84 non-AD individuals. Significant association between CETP genotypes or haplotypes and late onset AD was not detected in these two study cohorts. Moreover, the CETP genotypes and haplotypes were not significantly associated with AD when the populations were stratified for the presence or absence of apolipoprotein E4 (apoE4). In summary, CETP genetic variants were not associated with AD in two series.

KW - Alzheimers disease

KW - Apolipoprotein E

KW - Cholesteryl ester transfer protein

KW - Genetic association

KW - Haplotype

KW - Polymorphism

UR - http://www.scopus.com/inward/record.url?scp=18844389482&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=18844389482&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2005.01.078

DO - 10.1016/j.neulet.2005.01.078

M3 - Article

C2 - 15882786

AN - SCOPUS:18844389482

SN - 0304-3940

VL - 381

SP - 36

EP - 41

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1-2

ER -

Lack of genetic association of cholesteryl ester transfer protein polymorphisms with late onset Alzheimers disease

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this