Lack of genetic association of cholesteryl ester transfer protein polymorphisms with late onset Alzheimers disease

Haiyan Zhu, Rangaraj K. Gopalraj, Jeremiah F. Kelly, David A. Bennett, Steven Estus

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Dysregulation of cholesterol homeostasis may be associated with the pathogenesis of coronary artery disease (CAD) and Alzheimers disease (AD). Recently, several single nucleotide polymorphisms (SNPs) in cholesteryl ester transfer protein (CETP) were associated with altered plasma CETP concentrations, cholesterol concentrations and CAD. Hence, these CETP SNPs represent excellent candidates for evaluating association with AD. To date, one study has evaluated the association between a single CETP SNP and AD. In this study, we examined three CETP SNPs to evaluate the genetic association of CETP with late onset AD on two study cohorts: the Religious Orders Study (ROS) series, including 85 AD and 70 non-AD individuals, and the University of Kentucky (UKY) series, including 78 AD and 84 non-AD individuals. Significant association between CETP genotypes or haplotypes and late onset AD was not detected in these two study cohorts. Moreover, the CETP genotypes and haplotypes were not significantly associated with AD when the populations were stratified for the presence or absence of apolipoprotein E4 (apoE4). In summary, CETP genetic variants were not associated with AD in two series.

Original languageEnglish
Pages (from-to)36-41
Number of pages6
JournalNeuroscience Letters
Issue number1-2
StatePublished - Jun 10 2005

Bibliographical note

Funding Information:
The authors thank the UKY AD Research Center including William Markesbery and members of the Estus laboratory for helpful discussion. They also thank Joseph Pulliam for isolating the DNA from the ROS series. We thank the participants in the Religious Orders Study, the BRAiNS Study, and the patients at the UKY AD Center. This project was funded by the NIH (R01AG21545, 2P50AG05144, R01AG21362, P30AG10161, and R01AG15819).


  • Alzheimers disease
  • Apolipoprotein E
  • Cholesteryl ester transfer protein
  • Genetic association
  • Haplotype
  • Polymorphism

ASJC Scopus subject areas

  • General Neuroscience


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