Lack of initiating activity of the peroxisome proliferator ciprofibrate in two-stage hepatocarcinogenesis

H. P. Glauert, T. D. Clark

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

The peroxisome proliferator ciprofibrate was examined for its ability to initiate hepatocarcinogenesis in rats. Ciprofibrate was fed in the diet at levels of 0%, 0.01% and 0.025% for 2 weeks in order to induce steady-state peroxisome proliferation. Rats were then subjected to partial hepatectomy and then maintained for 6 months on a basal diet or one containing 0.05% phenobarbital. Ciprofibrate treatment did not increase the number or volume of altered hepatic foci (putative preneoplastic lesions). However, ciprofibrate treatment increased liver weights in a dose-dependent manner in rats which did not receive phenobarbital. It is concluded that ciprofibrate-induced peroxisome proliferation is not sufficient to induce initiation, but that a permanent change is produced which results in an increased liver weight.

Original languageEnglish
Pages (from-to)95-100
Number of pages6
JournalCancer Letters
Volume44
Issue number2
DOIs
StatePublished - Feb 1989

Keywords

  • altered hepatic foci
  • ciprofibrate
  • hepatocarcinogenesis
  • peroxisome

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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