Lack of relationship between brain (Na + + K +). Activated adenosine triphosphatase and the development of tolerance to ethanol in rats

T. Akera; R. H. Rech; W. J. Marquis; T. Tobin; T. M. Brody

Lack of relationship between brain (Na ⁺ + K ⁺). Activated adenosine triphosphatase and the development of tolerance to ethanol in rats

T. Akera, R. H. Rech, W. J. Marquis, T. Tobin, T. M. Brody

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22 Scopus citations

Abstract

The effects of chronic ethanol administration on brain (Na ⁺ + K ⁺) activated adenosine triphosphatase were re examined in rats. Despite the tolerance development to the behavioral depressant effects of ethanol as monitored by conditioned avoidance behavior and Rotarod performance, no remarkable change in (Na ⁺, Mg ⁺⁺, ATP) dependent binding of ³H ouabain or (Na ⁺ + K ⁺) activated adenosine triphosphatase activity of brain homogenates or microsomal fractions was observed after chronic ethanol treatments or during the subsequent withdrawal period. In contrast to a previous report, it is concluded that the (Na ⁺ + K ⁺) activated adenosine triphosphatase is not related to the development of central tolerance to ethanol in rats.

Original language	English
Pages (from-to)	594-601
Number of pages	8
Journal	Journal of Pharmacology and Experimental Therapeutics
Volume	185
Issue number	3
State	Published - 1973

ASJC Scopus subject areas

Molecular Medicine
Pharmacology

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abstract = "The effects of chronic ethanol administration on brain (Na + + K +) activated adenosine triphosphatase were re examined in rats. Despite the tolerance development to the behavioral depressant effects of ethanol as monitored by conditioned avoidance behavior and Rotarod performance, no remarkable change in (Na +, Mg ++, ATP) dependent binding of 3H ouabain or (Na + + K +) activated adenosine triphosphatase activity of brain homogenates or microsomal fractions was observed after chronic ethanol treatments or during the subsequent withdrawal period. In contrast to a previous report, it is concluded that the (Na + + K +) activated adenosine triphosphatase is not related to the development of central tolerance to ethanol in rats.",

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year = "1973",

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T1 - Lack of relationship between brain (Na + + K +). Activated adenosine triphosphatase and the development of tolerance to ethanol in rats

AU - Akera, T.

AU - Rech, R. H.

AU - Marquis, W. J.

AU - Tobin, T.

AU - Brody, T. M.

PY - 1973

Y1 - 1973

N2 - The effects of chronic ethanol administration on brain (Na + + K +) activated adenosine triphosphatase were re examined in rats. Despite the tolerance development to the behavioral depressant effects of ethanol as monitored by conditioned avoidance behavior and Rotarod performance, no remarkable change in (Na +, Mg ++, ATP) dependent binding of 3H ouabain or (Na + + K +) activated adenosine triphosphatase activity of brain homogenates or microsomal fractions was observed after chronic ethanol treatments or during the subsequent withdrawal period. In contrast to a previous report, it is concluded that the (Na + + K +) activated adenosine triphosphatase is not related to the development of central tolerance to ethanol in rats.

AB - The effects of chronic ethanol administration on brain (Na + + K +) activated adenosine triphosphatase were re examined in rats. Despite the tolerance development to the behavioral depressant effects of ethanol as monitored by conditioned avoidance behavior and Rotarod performance, no remarkable change in (Na +, Mg ++, ATP) dependent binding of 3H ouabain or (Na + + K +) activated adenosine triphosphatase activity of brain homogenates or microsomal fractions was observed after chronic ethanol treatments or during the subsequent withdrawal period. In contrast to a previous report, it is concluded that the (Na + + K +) activated adenosine triphosphatase is not related to the development of central tolerance to ethanol in rats.

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SN - 0022-3565

VL - 185

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JO - Journal of Pharmacology and Experimental Therapeutics

JF - Journal of Pharmacology and Experimental Therapeutics

IS - 3

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Lack of relationship between brain (Na ⁺ + K ⁺). Activated adenosine triphosphatase and the development of tolerance to ethanol in rats

Abstract

ASJC Scopus subject areas

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