Laparoscopic nissen fundoplication effectively relieves symptoms in patients with laryngopharyngeal reflux

Robert A. Catania, Stephen M. Kavic, J. Scott Roth, Tommy H. Lee, Tanya Meyer, George T. Fantry, Paul F. Castellanos, Adrian Park

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


The utility of laparoscopic Nissen fundoplication in the treatment of laryngopharyngeal reflux symptoms remains controversial. We hypothesized that a carefully selected population with these symptoms would benefit from antireflux surgery. Sixty-one consecutive patients have undergone antireflux surgery for laryngopharyngeal reflux at a single institution. Preoperative evaluation including upper endoscopy, laryngoscopy, and 24-h ambulatory pharyngeal pH probe monitoring confirmed the diagnosis. Patients completed two validated symptom assessment instruments preoperatively and at multiple time points postoperatively. Patients were followed for up to 3 years with a mean follow-up of 15.2 months. A significant improvement in reflux symptom index score (preoperative∈=∈31.5∈±∈7.4 vs 3 years∈=∈12. 4∈±∈10.9, p∈<∈0.01), laryngopharyngeal reflux health-related quality of life overall score (preoperative∈=∈55. 0∈±∈26.0 vs 3 years∈=∈11.3∈±∈13.9, p∈<∈0.01), and symptom domain scores (voice, cough, throat clearing, and swallowing) occured within 1 month of surgery and remained improved over the course ofthe study. Laparoscopic Nissen fundoplication is effective in relieving the symptoms of laryngopharyngeal reflux in a carefully selected patient population. Benefits are seen within 1 month of surgery and persist for at least 3 years.

Original languageEnglish
Pages (from-to)1579-1588
Number of pages10
JournalJournal of Gastrointestinal Surgery
Issue number12
StatePublished - Dec 2007


  • Antireflux surgery
  • Laparoscopic Nissen fundoplication
  • Laryngopharyngeal reflux
  • Outcomes
  • Quality of life

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology


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