Laponite stabilized endogenous antibacterial hydrogel as wet-tissue adhesive

Qing Shao; Wenjie Zhang; Jingjie Qi; Huiyun Liao; Hao Guo; Xiaoyan Tan; Bo Chi

doi:10.1016/j.jmbbm.2023.106009

Laponite stabilized endogenous antibacterial hydrogel as wet-tissue adhesive

Qing Shao, Wenjie Zhang, Jingjie Qi, Huiyun Liao, Hao Guo, Xiaoyan Tan, Bo Chi

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Clinical adhesives for suture-less wound closure remain the problem of poor biocompatibility, weak adhesive strength, and no endogenous antibacterial ability. Here, we designed a novel antibacterial hydrogel (CP-Lap hydrogel) consisting of chitosan and ε-polylysine after being modified with gallic acid (pyrogallol structure). The hydrogel was crosslinked by glutaraldehyde and Laponite via Schiff base and dynamic Laponite-pyrogallol interaction, free from heavy metal and oxidants. Given its dual crosslinking feature, the CP-Lap hydrogel exhibited adequate mechanical strength (150–240 kPa) and demonstrated swelling and degradation resistance. For a typical lap shear test with pigskin, the apparent adhesion strength of the CP-Lap hydrogel could be enhanced to ∼30 kPa benefiting from the O₂ blocking effect provided by nanoconfinement space between Laponite. In addition, the hydrogel showed effective antibacterial properties and excellent biocompatibility. The results indicated that this hydrogel has great potential for wound-closing bioadhesives to avoid chronic infections and further harm.

Original language	English
Article number	106009
Journal	Journal of the Mechanical Behavior of Biomedical Materials
Volume	145
DOIs	https://doi.org/10.1016/j.jmbbm.2023.106009
State	Published - Sep 2023

Bibliographical note

Publisher Copyright:
© 2023 Elsevier Ltd

Funding

This work was supported by the National Natural Science Foundation of China [grant number 31771049 ]; Foundation of key R & D Project of Jiangsu Province [grant number BE2018731 ]; Research Foundation of State Key Laboratory of Materials-Oriented Chemical Engineering [grant number ZK201806 , KL18-06 , and ZK201606 ]; The Six Talent Peaks Project of Jiangsu Province [grant number SWYY-046 ]; Natural Science Foundation of Jiangsu Province [grant number BK20200682 ]; and Postgraduate Research & Practice Innovation Program of Jiangsu Province [grant number KYCX23_1478 ].

Funders	Funder number
Foundation of key R & D Project of Jiangsu Province	BE2018731
Postgraduate Research and Practice Innovation Program of Jiangsu Province	KYCX23_1478
Research Foundation of State Key Laboratory of Materials-Oriented Chemical Engineering	ZK201606, ZK201806, KL18-06
National Natural Science Foundation of China (NSFC)	31771049
Natural Science Foundation of Jiangsu Province	BK20200682
Six Talent Peaks Project in Jiangsu Province	SWYY-046

Keywords

Hydrogel adhesives
Laponite
Mussel-inspired chemistry

ASJC Scopus subject areas

Biomaterials
Biomedical Engineering
Mechanics of Materials

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10.1016/j.jmbbm.2023.106009

Cite this

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title = "Laponite stabilized endogenous antibacterial hydrogel as wet-tissue adhesive",

abstract = "Clinical adhesives for suture-less wound closure remain the problem of poor biocompatibility, weak adhesive strength, and no endogenous antibacterial ability. Here, we designed a novel antibacterial hydrogel (CP-Lap hydrogel) consisting of chitosan and ε-polylysine after being modified with gallic acid (pyrogallol structure). The hydrogel was crosslinked by glutaraldehyde and Laponite via Schiff base and dynamic Laponite-pyrogallol interaction, free from heavy metal and oxidants. Given its dual crosslinking feature, the CP-Lap hydrogel exhibited adequate mechanical strength (150–240 kPa) and demonstrated swelling and degradation resistance. For a typical lap shear test with pigskin, the apparent adhesion strength of the CP-Lap hydrogel could be enhanced to ∼30 kPa benefiting from the O2 blocking effect provided by nanoconfinement space between Laponite. In addition, the hydrogel showed effective antibacterial properties and excellent biocompatibility. The results indicated that this hydrogel has great potential for wound-closing bioadhesives to avoid chronic infections and further harm.",

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author = "Qing Shao and Wenjie Zhang and Jingjie Qi and Huiyun Liao and Hao Guo and Xiaoyan Tan and Bo Chi",

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AU - Shao, Qing

AU - Zhang, Wenjie

AU - Qi, Jingjie

AU - Liao, Huiyun

AU - Guo, Hao

AU - Tan, Xiaoyan

AU - Chi, Bo

PY - 2023/9

Y1 - 2023/9

N2 - Clinical adhesives for suture-less wound closure remain the problem of poor biocompatibility, weak adhesive strength, and no endogenous antibacterial ability. Here, we designed a novel antibacterial hydrogel (CP-Lap hydrogel) consisting of chitosan and ε-polylysine after being modified with gallic acid (pyrogallol structure). The hydrogel was crosslinked by glutaraldehyde and Laponite via Schiff base and dynamic Laponite-pyrogallol interaction, free from heavy metal and oxidants. Given its dual crosslinking feature, the CP-Lap hydrogel exhibited adequate mechanical strength (150–240 kPa) and demonstrated swelling and degradation resistance. For a typical lap shear test with pigskin, the apparent adhesion strength of the CP-Lap hydrogel could be enhanced to ∼30 kPa benefiting from the O2 blocking effect provided by nanoconfinement space between Laponite. In addition, the hydrogel showed effective antibacterial properties and excellent biocompatibility. The results indicated that this hydrogel has great potential for wound-closing bioadhesives to avoid chronic infections and further harm.

AB - Clinical adhesives for suture-less wound closure remain the problem of poor biocompatibility, weak adhesive strength, and no endogenous antibacterial ability. Here, we designed a novel antibacterial hydrogel (CP-Lap hydrogel) consisting of chitosan and ε-polylysine after being modified with gallic acid (pyrogallol structure). The hydrogel was crosslinked by glutaraldehyde and Laponite via Schiff base and dynamic Laponite-pyrogallol interaction, free from heavy metal and oxidants. Given its dual crosslinking feature, the CP-Lap hydrogel exhibited adequate mechanical strength (150–240 kPa) and demonstrated swelling and degradation resistance. For a typical lap shear test with pigskin, the apparent adhesion strength of the CP-Lap hydrogel could be enhanced to ∼30 kPa benefiting from the O2 blocking effect provided by nanoconfinement space between Laponite. In addition, the hydrogel showed effective antibacterial properties and excellent biocompatibility. The results indicated that this hydrogel has great potential for wound-closing bioadhesives to avoid chronic infections and further harm.

KW - Hydrogel adhesives

KW - Laponite

KW - Mussel-inspired chemistry

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Laponite stabilized endogenous antibacterial hydrogel as wet-tissue adhesive

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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