Laponite stabilized endogenous antibacterial hydrogel as wet-tissue adhesive

Qing Shao, Wenjie Zhang, Jingjie Qi, Huiyun Liao, Hao Guo, Xiaoyan Tan, Bo Chi

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Clinical adhesives for suture-less wound closure remain the problem of poor biocompatibility, weak adhesive strength, and no endogenous antibacterial ability. Here, we designed a novel antibacterial hydrogel (CP-Lap hydrogel) consisting of chitosan and ε-polylysine after being modified with gallic acid (pyrogallol structure). The hydrogel was crosslinked by glutaraldehyde and Laponite via Schiff base and dynamic Laponite-pyrogallol interaction, free from heavy metal and oxidants. Given its dual crosslinking feature, the CP-Lap hydrogel exhibited adequate mechanical strength (150–240 kPa) and demonstrated swelling and degradation resistance. For a typical lap shear test with pigskin, the apparent adhesion strength of the CP-Lap hydrogel could be enhanced to ∼30 kPa benefiting from the O2 blocking effect provided by nanoconfinement space between Laponite. In addition, the hydrogel showed effective antibacterial properties and excellent biocompatibility. The results indicated that this hydrogel has great potential for wound-closing bioadhesives to avoid chronic infections and further harm.

Original languageEnglish
Article number106009
JournalJournal of the Mechanical Behavior of Biomedical Materials
Volume145
DOIs
StatePublished - Sep 2023

Bibliographical note

Publisher Copyright:
© 2023 Elsevier Ltd

Keywords

  • Hydrogel adhesives
  • Laponite
  • Mussel-inspired chemistry

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Mechanics of Materials

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