Large-animal models of acute respiratory distress syndrome

Research output: Contribution to journalReview articlepeer-review

97 Scopus citations


Acute respiratory distress syndrome (ARDS) is characterized by an acute inflammatory response that compromises alveolar-capillary membrane integrity. Clinical symptoms include refractory hypoxemia, noncardiogenic edema, and decreased lung compliance. The purpose of this review is to summarize the different ARDS large-animal models in terms of similarity to the clinical disease and underlying pathophysiology. The repeated lavage, oleic acid, endotoxin, and smoke/burn ARDS models will be discussed in this review. While each model has significant benefits, none is without weaknesses. Thus, the choice of large-animal ARDS model must be carefully considered based upon the study focus and investigative team experience.

Original languageEnglish
Pages (from-to)1331-1339
Number of pages9
JournalAnnals of Thoracic Surgery
Issue number4
StatePublished - Apr 2012

Bibliographical note

Funding Information:
Supported by the Johnston-Wright Endowment, University of Kentucky, Department of Surgery.

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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