Lateral Corticospinal Tract and Dorsal Column Damage: Predictive Relationships With Motor and Sensory Scores at Discharge From Acute Rehabilitation After Spinal Cord Injury

Andrew C. Smith; Denise R. O'Dell; Stephanie R. Albin; Jeffrey C. Berliner; David Dungan; Eli Robinson; James M. Elliott; Julio Carballido-Gamio; Jennifer Stevens-Lapsley; Kenneth A. Weber

doi:10.1016/j.apmr.2021.07.792

Lateral Corticospinal Tract and Dorsal Column Damage: Predictive Relationships With Motor and Sensory Scores at Discharge From Acute Rehabilitation After Spinal Cord Injury

Andrew C. Smith, Denise R. O'Dell, Stephanie R. Albin, Jeffrey C. Berliner, David Dungan, Eli Robinson, James M. Elliott, Julio Carballido-Gamio, Jennifer Stevens-Lapsley, Kenneth A. Weber

Physical Therapy

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Objective: To determine if lateral corticospinal tract (LCST) integrity demonstrates a significant predictive relationship with future ipsilateral lower extremity motor function (LEMS) and if dorsal column (DC) integrity demonstrates a significant predictive relationship with future light touch (LT) sensory function post spinal cord injury (SCI) at time of discharge from inpatient rehabilitation. Design: Retrospective analyses of imaging and clinical outcomes. Setting: University and academic hospital. Participants: A total of 151 participants (N=151) with SCI. Interventions: Inpatient rehabilitation. Main Outcome Measures: LEMS and LT scores at discharge from inpatient rehabilitation. Results: In 151 participants, right LCST spared tissue demonstrated a significant predictive relationship with right LEMS percentage recovered (β=0.56; 95% confidence interval [CI], 0.37-0.73; R=0.43; P<.001). Left LCST spared tissue demonstrated a significant predictive relationship with left LEMS percentage recovered (β=0.66; 95% CI, 0.50-0.82; R=0.51; P<.001). DC spared tissue demonstrated a significant predictive relationship with LT percentage recovered (β=0.69; 95% CI, 0.52-0.87; R=0.55; P<.001). When subgrouping the participants into motor complete vs incomplete SCI, motor relationships were no longer significant, but the sensory relationship remained significant. Those who had no voluntary motor function but recovered some also had significantly greater LCST spared tissue than those who did not recover motor function. Conclusions: LCST demonstrated significant moderate predictive relationships with lower extremity motor function at the time of discharge from inpatient rehabilitation, in an ipsilesional manner. DC integrity demonstrated a significant moderate predictive relationship with recovered function of LT. With further development, these neuroimaging methods might be used to predict potential deficits after SCI and to provide corresponding targeted interventions.

Original language	English
Pages (from-to)	62-68
Number of pages	7
Journal	Archives of Physical Medicine and Rehabilitation
Volume	103
Issue number	1
DOIs	https://doi.org/10.1016/j.apmr.2021.07.792
State	Published - Jan 2022

Bibliographical note

Funding Information:
We thank the Craig Hospital Research Board for their assistance with this project.

Funding Information:
Supported by the National Institute of Child Health and Development (grant no. R03HD094577) and the National Institute of Neurological Disorders and Stroke (grant nos. K23NS104211, L30NS108301). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Publisher Copyright:
© 2021 The American Congress of Rehabilitation Medicine

Keywords

Cervical cord
Magnetic resonance imaging
Pyramidal tracts
Rehabilitation
Spinal cord injuries

ASJC Scopus subject areas

Physical Therapy, Sports Therapy and Rehabilitation
Rehabilitation

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10.1016/j.apmr.2021.07.792

Cite this

Smith, A. C., O'Dell, D. R., Albin, S. R., Berliner, J. C., Dungan, D., Robinson, E., Elliott, J. M., Carballido-Gamio, J., Stevens-Lapsley, J., & Weber, K. A. (2022). Lateral Corticospinal Tract and Dorsal Column Damage: Predictive Relationships With Motor and Sensory Scores at Discharge From Acute Rehabilitation After Spinal Cord Injury. Archives of Physical Medicine and Rehabilitation, 103(1), 62-68. https://doi.org/10.1016/j.apmr.2021.07.792

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title = "Lateral Corticospinal Tract and Dorsal Column Damage: Predictive Relationships With Motor and Sensory Scores at Discharge From Acute Rehabilitation After Spinal Cord Injury",

abstract = "Objective: To determine if lateral corticospinal tract (LCST) integrity demonstrates a significant predictive relationship with future ipsilateral lower extremity motor function (LEMS) and if dorsal column (DC) integrity demonstrates a significant predictive relationship with future light touch (LT) sensory function post spinal cord injury (SCI) at time of discharge from inpatient rehabilitation. Design: Retrospective analyses of imaging and clinical outcomes. Setting: University and academic hospital. Participants: A total of 151 participants (N=151) with SCI. Interventions: Inpatient rehabilitation. Main Outcome Measures: LEMS and LT scores at discharge from inpatient rehabilitation. Results: In 151 participants, right LCST spared tissue demonstrated a significant predictive relationship with right LEMS percentage recovered (β=0.56; 95% confidence interval [CI], 0.37-0.73; R=0.43; P<.001). Left LCST spared tissue demonstrated a significant predictive relationship with left LEMS percentage recovered (β=0.66; 95% CI, 0.50-0.82; R=0.51; P<.001). DC spared tissue demonstrated a significant predictive relationship with LT percentage recovered (β=0.69; 95% CI, 0.52-0.87; R=0.55; P<.001). When subgrouping the participants into motor complete vs incomplete SCI, motor relationships were no longer significant, but the sensory relationship remained significant. Those who had no voluntary motor function but recovered some also had significantly greater LCST spared tissue than those who did not recover motor function. Conclusions: LCST demonstrated significant moderate predictive relationships with lower extremity motor function at the time of discharge from inpatient rehabilitation, in an ipsilesional manner. DC integrity demonstrated a significant moderate predictive relationship with recovered function of LT. With further development, these neuroimaging methods might be used to predict potential deficits after SCI and to provide corresponding targeted interventions.",

keywords = "Cervical cord, Magnetic resonance imaging, Pyramidal tracts, Rehabilitation, Spinal cord injuries",

author = "Smith, {Andrew C.} and O'Dell, {Denise R.} and Albin, {Stephanie R.} and Berliner, {Jeffrey C.} and David Dungan and Eli Robinson and Elliott, {James M.} and Julio Carballido-Gamio and Jennifer Stevens-Lapsley and Weber, {Kenneth A.}",

note = "Funding Information: We thank the Craig Hospital Research Board for their assistance with this project. Funding Information: Supported by the National Institute of Child Health and Development (grant no. R03HD094577) and the National Institute of Neurological Disorders and Stroke (grant nos. K23NS104211, L30NS108301). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Publisher Copyright: {\textcopyright} 2021 The American Congress of Rehabilitation Medicine",

year = "2022",

month = jan,

doi = "10.1016/j.apmr.2021.07.792",

language = "English",

volume = "103",

pages = "62--68",

number = "1",

}

Smith, AC, O'Dell, DR, Albin, SR, Berliner, JC, Dungan, D, Robinson, E, Elliott, JM, Carballido-Gamio, J, Stevens-Lapsley, J & Weber, KA 2022, 'Lateral Corticospinal Tract and Dorsal Column Damage: Predictive Relationships With Motor and Sensory Scores at Discharge From Acute Rehabilitation After Spinal Cord Injury', Archives of Physical Medicine and Rehabilitation, vol. 103, no. 1, pp. 62-68. https://doi.org/10.1016/j.apmr.2021.07.792

Lateral Corticospinal Tract and Dorsal Column Damage: Predictive Relationships With Motor and Sensory Scores at Discharge From Acute Rehabilitation After Spinal Cord Injury. / Smith, Andrew C.; O'Dell, Denise R.; Albin, Stephanie R. et al.
In: Archives of Physical Medicine and Rehabilitation, Vol. 103, No. 1, 01.2022, p. 62-68.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Lateral Corticospinal Tract and Dorsal Column Damage

T2 - Predictive Relationships With Motor and Sensory Scores at Discharge From Acute Rehabilitation After Spinal Cord Injury

AU - Smith, Andrew C.

AU - O'Dell, Denise R.

AU - Albin, Stephanie R.

AU - Berliner, Jeffrey C.

AU - Dungan, David

AU - Robinson, Eli

AU - Elliott, James M.

AU - Carballido-Gamio, Julio

AU - Stevens-Lapsley, Jennifer

AU - Weber, Kenneth A.

N1 - Funding Information: We thank the Craig Hospital Research Board for their assistance with this project. Funding Information: Supported by the National Institute of Child Health and Development (grant no. R03HD094577) and the National Institute of Neurological Disorders and Stroke (grant nos. K23NS104211, L30NS108301). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Publisher Copyright: © 2021 The American Congress of Rehabilitation Medicine

PY - 2022/1

Y1 - 2022/1

N2 - Objective: To determine if lateral corticospinal tract (LCST) integrity demonstrates a significant predictive relationship with future ipsilateral lower extremity motor function (LEMS) and if dorsal column (DC) integrity demonstrates a significant predictive relationship with future light touch (LT) sensory function post spinal cord injury (SCI) at time of discharge from inpatient rehabilitation. Design: Retrospective analyses of imaging and clinical outcomes. Setting: University and academic hospital. Participants: A total of 151 participants (N=151) with SCI. Interventions: Inpatient rehabilitation. Main Outcome Measures: LEMS and LT scores at discharge from inpatient rehabilitation. Results: In 151 participants, right LCST spared tissue demonstrated a significant predictive relationship with right LEMS percentage recovered (β=0.56; 95% confidence interval [CI], 0.37-0.73; R=0.43; P<.001). Left LCST spared tissue demonstrated a significant predictive relationship with left LEMS percentage recovered (β=0.66; 95% CI, 0.50-0.82; R=0.51; P<.001). DC spared tissue demonstrated a significant predictive relationship with LT percentage recovered (β=0.69; 95% CI, 0.52-0.87; R=0.55; P<.001). When subgrouping the participants into motor complete vs incomplete SCI, motor relationships were no longer significant, but the sensory relationship remained significant. Those who had no voluntary motor function but recovered some also had significantly greater LCST spared tissue than those who did not recover motor function. Conclusions: LCST demonstrated significant moderate predictive relationships with lower extremity motor function at the time of discharge from inpatient rehabilitation, in an ipsilesional manner. DC integrity demonstrated a significant moderate predictive relationship with recovered function of LT. With further development, these neuroimaging methods might be used to predict potential deficits after SCI and to provide corresponding targeted interventions.

AB - Objective: To determine if lateral corticospinal tract (LCST) integrity demonstrates a significant predictive relationship with future ipsilateral lower extremity motor function (LEMS) and if dorsal column (DC) integrity demonstrates a significant predictive relationship with future light touch (LT) sensory function post spinal cord injury (SCI) at time of discharge from inpatient rehabilitation. Design: Retrospective analyses of imaging and clinical outcomes. Setting: University and academic hospital. Participants: A total of 151 participants (N=151) with SCI. Interventions: Inpatient rehabilitation. Main Outcome Measures: LEMS and LT scores at discharge from inpatient rehabilitation. Results: In 151 participants, right LCST spared tissue demonstrated a significant predictive relationship with right LEMS percentage recovered (β=0.56; 95% confidence interval [CI], 0.37-0.73; R=0.43; P<.001). Left LCST spared tissue demonstrated a significant predictive relationship with left LEMS percentage recovered (β=0.66; 95% CI, 0.50-0.82; R=0.51; P<.001). DC spared tissue demonstrated a significant predictive relationship with LT percentage recovered (β=0.69; 95% CI, 0.52-0.87; R=0.55; P<.001). When subgrouping the participants into motor complete vs incomplete SCI, motor relationships were no longer significant, but the sensory relationship remained significant. Those who had no voluntary motor function but recovered some also had significantly greater LCST spared tissue than those who did not recover motor function. Conclusions: LCST demonstrated significant moderate predictive relationships with lower extremity motor function at the time of discharge from inpatient rehabilitation, in an ipsilesional manner. DC integrity demonstrated a significant moderate predictive relationship with recovered function of LT. With further development, these neuroimaging methods might be used to predict potential deficits after SCI and to provide corresponding targeted interventions.

KW - Cervical cord

KW - Magnetic resonance imaging

KW - Pyramidal tracts

KW - Rehabilitation

KW - Spinal cord injuries

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SN - 0003-9993

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ER -

Lateral Corticospinal Tract and Dorsal Column Damage: Predictive Relationships With Motor and Sensory Scores at Discharge From Acute Rehabilitation After Spinal Cord Injury

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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