Latex allergy in children with spina bifida

Thomas Pittman, Jean Kiburz, Keith Gabriel, George Steinhardt, Dianne Williams, Jay Slater

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


We studied the prevalence of latex-specific IgE among the children in our myelomeningocele clinic and several groups of controls using skin tests, a commercially available ELISA and an in-house RAST. Thirty-nine of 83 (47%) children with myelomeningocele had antibodies directed against latex as did 6 of 40 (15.7%) chronically ill controls, 4 of 105 (3.8%) medical controls and 2 of 75 (2.7%) well controls. Within each study group the likelihood of a positive skin test increased with the number of operations the subject had undergone. Children with myelomeningocele were much more likely to have antibodies to latex than were chronically ill controls with similar surgical histories. A retrospective chart review of 18 years and a total of 646 operations disclosed only one episode of intraoperative anaphylaxis which appeared to be related to latex within our study group.

Original languageEnglish
Pages (from-to)96-100
Number of pages5
JournalPediatric Neurosurgery
Issue number2
StatePublished - 1955


  • Intraoperative anaphylaxis
  • Latex allergy
  • Myelomeningocele

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery
  • Clinical Neurology


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