Mucin networks are lubricous biofunctional coats formed through the continuous deposition of mucin glycoproteins. Previously, we demonstrated the synthesis of a mucin mimic using biotinylated-filomicelles crosslinked via streptavidin using a layer-by-layer approach. These networks recreate the fibrous nature of mucin and can serve as a drug-releasing network. In this work, the ability to vary the network properties by blending filomicelles with spherical micelles is demonstrated. In addition, the deposition of a dense polymer coating on the mucin network was shown to act as a barrier to control diffusion and improved the structural stability under simulated oral chemical conditions. These biomimetic coatings can be utilized as a delivery system, providing a tunable drug release for oral applications.
|Number of pages||13|
|State||Published - Feb 1 2016|
Bibliographical noteFunding Information:
This work was funded by National Institutes of Health (Grant R03 DE019496). Authors acknowledge Nihar Shah (Bluegrass Advanced Materials, LLC, Lexington, KY) for his insightful discussions.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
- oral drug delivery
ASJC Scopus subject areas
- Polymers and Plastics
- Materials Chemistry