Layer-by-Layers of Polymeric Micelles as a Biomimetic Drug-Releasing Network

Sundar P. Authimoolam, Andrew L. Lakes, David A. Puleo, Thomas D. Dziubla

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Mucin networks are lubricous biofunctional coats formed through the continuous deposition of mucin glycoproteins. Previously, we demonstrated the synthesis of a mucin mimic using biotinylated-filomicelles crosslinked via streptavidin using a layer-by-layer approach. These networks recreate the fibrous nature of mucin and can serve as a drug-releasing network. In this work, the ability to vary the network properties by blending filomicelles with spherical micelles is demonstrated. In addition, the deposition of a dense polymer coating on the mucin network was shown to act as a barrier to control diffusion and improved the structural stability under simulated oral chemical conditions. These biomimetic coatings can be utilized as a delivery system, providing a tunable drug release for oral applications.

Original languageEnglish
Pages (from-to)242-254
Number of pages13
JournalMacromolecular Bioscience
Issue number2
StatePublished - Feb 1 2016

Bibliographical note

Publisher Copyright:
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


  • biomimetic
  • biotin-streptavidin
  • filomicelles
  • mucin
  • oral drug delivery

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry


Dive into the research topics of 'Layer-by-Layers of Polymeric Micelles as a Biomimetic Drug-Releasing Network'. Together they form a unique fingerprint.

Cite this