Left and right ventricular dyssynchrony and strains from cardiovascular magnetic resonance feature tracking do not predict deterioration of ventricular function in patients with repaired tetralogy of Fallot

Linyuan Jing; Gregory J. Wehner; Jonathan D. Suever; Richard J. Charnigo; Sudad Alhadad; Evan Stearns; Dimitri Mojsejenko; Christopher M. Haggerty; Kelsey Hickey; Anne Marie Valente; Tal Geva; Andrew J. Powell; Brandon K. Fornwalt

doi:10.1186/s12968-016-0268-8

Left and right ventricular dyssynchrony and strains from cardiovascular magnetic resonance feature tracking do not predict deterioration of ventricular function in patients with repaired tetralogy of Fallot

Linyuan Jing, Gregory J. Wehner, Jonathan D. Suever, Richard J. Charnigo, Sudad Alhadad, Evan Stearns, Dimitri Mojsejenko, Christopher M. Haggerty, Kelsey Hickey, Anne Marie Valente, Tal Geva, Andrew J. Powell, Brandon K. Fornwalt

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Background: Patients with repaired tetralogy of Fallot (rTOF) suffer from progressive ventricular dysfunction decades after their surgical repair. We hypothesized that measures of ventricular strain and dyssynchrony would predict deterioration of ventricular function in patients with rTOF. Methods: A database search identified all patients at a single institution with rTOF who underwent cardiovascular magnetic resonance (CMR) at least twice, >6 months apart, without intervening surgical or catheter procedures. Seven primary predictors were derived from the first CMR using a custom feature tracking algorithm: left (LV), right (RV) and inter-ventricular dyssynchrony, LV and RV peak global circumferential strains, and LV and RV peak global longitudinal strains. Three outcomes were defined, whose changes were assessed over time: RV end-diastolic volume, and RV and LV ejection fraction. Multivariate linear mixed models were fit to investigate relationships of outcomes to predictors and ten potential baseline confounders. Results: One hundred fifty-three patients with rTOF (23 ± 14 years, 50 % male) were included. The mean follow-up duration between the first and last CMR was 2.9 ± 1.3 years. After adjustment for confounders, none of the 7 primary predictors were significantly associated with change over time in the 3 outcome variables. Only 1-17 % of the variability in the change over time in the outcome variables was explained by the baseline predictors and potential confounders. Conclusions: In patients with repaired tetralogy of Fallot, ventricular dyssynchrony and global strain derived from cine CMR were not significantly related to changes in ventricular size and function over time. The ability to predict deterioration in ventricular function in patients with rTOF using current methods is limited.

Original language	English
Article number	268
Journal	Journal of Cardiovascular Magnetic Resonance
Volume	18
Issue number	1
DOIs	https://doi.org/10.1186/s12968-016-0268-8
State	Published - Aug 22 2016

Bibliographical note

Funding Information:
This work was supported by a National Institutes of Health (NIH) Director’s Early Independence Award (DP5 OD-012132), NIH grant number KL2 RR033171 from the National Center for Research Resources and the National Center for Advancing Translational Sciences, and American Heart Association Great Rivers Affiliate via grant 14POST20310025. The content is solely the responsibility of the authors and does not necessarily represent the official views of NIH.

Publisher Copyright:
© 2016 The Author(s).

Keywords

Cardiac strain
Cardiovascular magnetic resonance
Congenital heart disease
Dyssynchrony
Tetralogy of Fallot

ASJC Scopus subject areas

Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging
Cardiology and Cardiovascular Medicine

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Jing, L., Wehner, G. J., Suever, J. D., Charnigo, R. J., Alhadad, S., Stearns, E., Mojsejenko, D., Haggerty, C. M., Hickey, K., Valente, A. M., Geva, T., Powell, A. J., & Fornwalt, B. K. (2016). Left and right ventricular dyssynchrony and strains from cardiovascular magnetic resonance feature tracking do not predict deterioration of ventricular function in patients with repaired tetralogy of Fallot. Journal of Cardiovascular Magnetic Resonance, 18(1), [268]. https://doi.org/10.1186/s12968-016-0268-8

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title = "Left and right ventricular dyssynchrony and strains from cardiovascular magnetic resonance feature tracking do not predict deterioration of ventricular function in patients with repaired tetralogy of Fallot",

abstract = "Background: Patients with repaired tetralogy of Fallot (rTOF) suffer from progressive ventricular dysfunction decades after their surgical repair. We hypothesized that measures of ventricular strain and dyssynchrony would predict deterioration of ventricular function in patients with rTOF. Methods: A database search identified all patients at a single institution with rTOF who underwent cardiovascular magnetic resonance (CMR) at least twice, >6 months apart, without intervening surgical or catheter procedures. Seven primary predictors were derived from the first CMR using a custom feature tracking algorithm: left (LV), right (RV) and inter-ventricular dyssynchrony, LV and RV peak global circumferential strains, and LV and RV peak global longitudinal strains. Three outcomes were defined, whose changes were assessed over time: RV end-diastolic volume, and RV and LV ejection fraction. Multivariate linear mixed models were fit to investigate relationships of outcomes to predictors and ten potential baseline confounders. Results: One hundred fifty-three patients with rTOF (23 ± 14 years, 50 % male) were included. The mean follow-up duration between the first and last CMR was 2.9 ± 1.3 years. After adjustment for confounders, none of the 7 primary predictors were significantly associated with change over time in the 3 outcome variables. Only 1-17 % of the variability in the change over time in the outcome variables was explained by the baseline predictors and potential confounders. Conclusions: In patients with repaired tetralogy of Fallot, ventricular dyssynchrony and global strain derived from cine CMR were not significantly related to changes in ventricular size and function over time. The ability to predict deterioration in ventricular function in patients with rTOF using current methods is limited.",

keywords = "Cardiac strain, Cardiovascular magnetic resonance, Congenital heart disease, Dyssynchrony, Tetralogy of Fallot",

author = "Linyuan Jing and Wehner, {Gregory J.} and Suever, {Jonathan D.} and Charnigo, {Richard J.} and Sudad Alhadad and Evan Stearns and Dimitri Mojsejenko and Haggerty, {Christopher M.} and Kelsey Hickey and Valente, {Anne Marie} and Tal Geva and Powell, {Andrew J.} and Fornwalt, {Brandon K.}",

note = "Funding Information: This work was supported by a National Institutes of Health (NIH) Director{\textquoteright}s Early Independence Award (DP5 OD-012132), NIH grant number KL2 RR033171 from the National Center for Research Resources and the National Center for Advancing Translational Sciences, and American Heart Association Great Rivers Affiliate via grant 14POST20310025. The content is solely the responsibility of the authors and does not necessarily represent the official views of NIH. Publisher Copyright: {\textcopyright} 2016 The Author(s).",

year = "2016",

month = aug,

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doi = "10.1186/s12968-016-0268-8",

language = "English",

volume = "18",

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Jing, L, Wehner, GJ, Suever, JD, Charnigo, RJ, Alhadad, S, Stearns, E, Mojsejenko, D, Haggerty, CM, Hickey, K, Valente, AM, Geva, T, Powell, AJ & Fornwalt, BK 2016, 'Left and right ventricular dyssynchrony and strains from cardiovascular magnetic resonance feature tracking do not predict deterioration of ventricular function in patients with repaired tetralogy of Fallot', Journal of Cardiovascular Magnetic Resonance, vol. 18, no. 1, 268. https://doi.org/10.1186/s12968-016-0268-8

Left and right ventricular dyssynchrony and strains from cardiovascular magnetic resonance feature tracking do not predict deterioration of ventricular function in patients with repaired tetralogy of Fallot. / Jing, Linyuan; Wehner, Gregory J.; Suever, Jonathan D. et al.

In: Journal of Cardiovascular Magnetic Resonance, Vol. 18, No. 1, 268, 22.08.2016.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Left and right ventricular dyssynchrony and strains from cardiovascular magnetic resonance feature tracking do not predict deterioration of ventricular function in patients with repaired tetralogy of Fallot

AU - Jing, Linyuan

AU - Wehner, Gregory J.

AU - Suever, Jonathan D.

AU - Charnigo, Richard J.

AU - Alhadad, Sudad

AU - Stearns, Evan

AU - Mojsejenko, Dimitri

AU - Haggerty, Christopher M.

AU - Hickey, Kelsey

AU - Valente, Anne Marie

AU - Geva, Tal

AU - Powell, Andrew J.

AU - Fornwalt, Brandon K.

N1 - Funding Information: This work was supported by a National Institutes of Health (NIH) Director’s Early Independence Award (DP5 OD-012132), NIH grant number KL2 RR033171 from the National Center for Research Resources and the National Center for Advancing Translational Sciences, and American Heart Association Great Rivers Affiliate via grant 14POST20310025. The content is solely the responsibility of the authors and does not necessarily represent the official views of NIH. Publisher Copyright: © 2016 The Author(s).

PY - 2016/8/22

Y1 - 2016/8/22

N2 - Background: Patients with repaired tetralogy of Fallot (rTOF) suffer from progressive ventricular dysfunction decades after their surgical repair. We hypothesized that measures of ventricular strain and dyssynchrony would predict deterioration of ventricular function in patients with rTOF. Methods: A database search identified all patients at a single institution with rTOF who underwent cardiovascular magnetic resonance (CMR) at least twice, >6 months apart, without intervening surgical or catheter procedures. Seven primary predictors were derived from the first CMR using a custom feature tracking algorithm: left (LV), right (RV) and inter-ventricular dyssynchrony, LV and RV peak global circumferential strains, and LV and RV peak global longitudinal strains. Three outcomes were defined, whose changes were assessed over time: RV end-diastolic volume, and RV and LV ejection fraction. Multivariate linear mixed models were fit to investigate relationships of outcomes to predictors and ten potential baseline confounders. Results: One hundred fifty-three patients with rTOF (23 ± 14 years, 50 % male) were included. The mean follow-up duration between the first and last CMR was 2.9 ± 1.3 years. After adjustment for confounders, none of the 7 primary predictors were significantly associated with change over time in the 3 outcome variables. Only 1-17 % of the variability in the change over time in the outcome variables was explained by the baseline predictors and potential confounders. Conclusions: In patients with repaired tetralogy of Fallot, ventricular dyssynchrony and global strain derived from cine CMR were not significantly related to changes in ventricular size and function over time. The ability to predict deterioration in ventricular function in patients with rTOF using current methods is limited.

AB - Background: Patients with repaired tetralogy of Fallot (rTOF) suffer from progressive ventricular dysfunction decades after their surgical repair. We hypothesized that measures of ventricular strain and dyssynchrony would predict deterioration of ventricular function in patients with rTOF. Methods: A database search identified all patients at a single institution with rTOF who underwent cardiovascular magnetic resonance (CMR) at least twice, >6 months apart, without intervening surgical or catheter procedures. Seven primary predictors were derived from the first CMR using a custom feature tracking algorithm: left (LV), right (RV) and inter-ventricular dyssynchrony, LV and RV peak global circumferential strains, and LV and RV peak global longitudinal strains. Three outcomes were defined, whose changes were assessed over time: RV end-diastolic volume, and RV and LV ejection fraction. Multivariate linear mixed models were fit to investigate relationships of outcomes to predictors and ten potential baseline confounders. Results: One hundred fifty-three patients with rTOF (23 ± 14 years, 50 % male) were included. The mean follow-up duration between the first and last CMR was 2.9 ± 1.3 years. After adjustment for confounders, none of the 7 primary predictors were significantly associated with change over time in the 3 outcome variables. Only 1-17 % of the variability in the change over time in the outcome variables was explained by the baseline predictors and potential confounders. Conclusions: In patients with repaired tetralogy of Fallot, ventricular dyssynchrony and global strain derived from cine CMR were not significantly related to changes in ventricular size and function over time. The ability to predict deterioration in ventricular function in patients with rTOF using current methods is limited.

KW - Cardiac strain

KW - Cardiovascular magnetic resonance

KW - Congenital heart disease

KW - Dyssynchrony

KW - Tetralogy of Fallot

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U2 - 10.1186/s12968-016-0268-8

DO - 10.1186/s12968-016-0268-8

M3 - Article

C2 - 27549809

AN - SCOPUS:84983371519

VL - 18

IS - 1

M1 - 268

ER -

Jing L, Wehner GJ, Suever JD, Charnigo RJ, Alhadad S, Stearns E et al. Left and right ventricular dyssynchrony and strains from cardiovascular magnetic resonance feature tracking do not predict deterioration of ventricular function in patients with repaired tetralogy of Fallot. Journal of Cardiovascular Magnetic Resonance. 2016 Aug 22;18(1):268. doi: 10.1186/s12968-016-0268-8

Left and right ventricular dyssynchrony and strains from cardiovascular magnetic resonance feature tracking do not predict deterioration of ventricular function in patients with repaired tetralogy of Fallot

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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