Left atrial systolic force and cardiac markers of preclinical disease in hypertensive patients: The Hypertension Genetic Epidemiology Network (HyperGEN) study

Marcello Chinali, Giovanni De Simone, Jennifer E. Liu, Jonathan N. Bella, Albert Oberman, Paul N. Hopkins, Dalane W. Kitzman, Debeeru C. Rao, Donna K. Arnett, Richard B. Devereux

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Background: Left atrial systolic force (LASF) has been recently reported to be associated with prolonged left ventricular (LV) relaxation and concentric LV geometry in a clinical setting. This study analyzes the association of increased LASF to LV geometry and function in hypertensive patients from a population study. Methods: Doppler echocardiographic findings were examined in 684 subjects with treated hypertension and without prevalent cardiovascular disease from the Hypertension Genetic Epidemiology Network (HyperGEN) Study (426 African American, 448 female, 125 diabetic, 174 obese; age 53.8 ± 10.8 years). The LASF was assessed from the mitral orifice area and pulse-wave Doppler peak A flow velocity. The LASF was defined as being high if >14.33 kdynes (90th percentile of the normal distribution in 246 normal adults). Results: The LASF was high in 269 participants (39.3% of study population), who were older and had higher mean body mass index (all P < .01). Participants with high LASF had higher systolic BP and heart rate (both P < .01) but similar diastolic BP. After controlling for covariates, participants with high LASF exhibited higher LV dimensions and mass than those with normal LASF (all P < .01). The prevalence of LV hypertrophy was also higher (P < .001). Participants with high LASF exhibited normal ejection fraction, higher stroke volume, cardiac output, E and A velocities, slower E deceleration, and lower E/A ratio than those with normal LASF (all P < .01). Conclusions: Enhanced LASF is associated with LV hypertrophy, normal LV chamber function, increased cardiac output, and prolonged relaxation. The LASF is a preload-dependent measure.

Original languageEnglish
Pages (from-to)899-905
Number of pages7
JournalAmerican Journal of Hypertension
Issue number7
StatePublished - Jul 2005

Bibliographical note

Funding Information:
This work was supported by grant RO1 HL55673 and by cooperative agreement grants HL54471, HL54472, HL54473, HL54495, HL54496, HL54509, HL54515 from the National Heart, Lung and Blood Institute, Bethesda, MD, and grant M10RR0047-34 (GCRC) from the National Institutes of Health, Bethesda, MD.


  • Atrial function
  • Cardiac hypertrophy
  • Diastole
  • Echocardiography
  • Hemodynamics
  • Hypertension

ASJC Scopus subject areas

  • Internal Medicine


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