Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

M. Maffei, J. Halaas, E. Ravussin, R. E. Pratley, G. H. Lee, Y. Zhang, H. Fei, S. Kim, R. Lallone, S. Ranganathan, P. A. Kern, J. M. Friedman

Research output: Contribution to journalArticlepeer-review

3388 Scopus citations

Abstract

Leptin, the gene product of the obese gene, may play an important role in regulating body weight by signalling the size of the adipose tissue mass. Plasma leptin was found to be highly correlated with body mass index (BMI) in rodents and in 87 lean and obese humans. In humans, there was variability in plasma leptin at each BMI suggesting that there are differences in its secretion rate from fat. Weight loss due to food restriction was associated with a decrease in plasma leptin in samples from mice and obese humans.

Original languageEnglish
Pages (from-to)1155-1161
Number of pages7
JournalNature Medicine
Volume1
Issue number11
DOIs
StatePublished - Nov 1995

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

Fingerprint

Dive into the research topics of 'Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects'. Together they form a unique fingerprint.

Cite this