From birth to adulthood, the gut microbiota matures from a simple community dominated by a few major bacterial groups into a highly diverse ecosystem that provides both benefits and challenges to the host. Currently there is great interest in identifying environmental and host factors that shape the development of our gut microbiota. Breast milk is a rich source of maternal antibodies, which provide the first source of adaptive immunity in the newborn’s intestinal tract. In this addendum, we summarize our recent data demonstrating that maternal antibodies in breast milk promote long-term intestinal homeostasis in suckling mice by regulating the gut microbiota and host gene expression. We also discuss important unanswered questions, future directions for research in this field, and implications for human health and disease.
|Number of pages||6|
|State||Published - 2014|
Bibliographical noteFunding Information:
This work was supported by an NIH grant AI069027 (and an associated Ameri can Recovery and Reinvestment Act sup plement), a Senior Research Award from the Crohn’s and Colitis Foundation of America (CCFA), and a grant from the Kentucky Bioinformatics Research Infra structure Network to CSK; a Senior Research Award from the CCFA to DAC; and NIH grants NCATS UL1TR000117, NCRR 5P20RR016481-12 and NIGMS 8 P20 GM103436-12 to AJS.
© Eric W Rogier, Aubrey L Frantz, Maria EC Bruno, Leia Wedlund, Donald A Cohen, Arnold J Stromberg, and Charlotte S Kaetzel.
- Gene expression
- Gut microbiota
- Inflammatory bowel disease
- Intestinal epithelial cells
- Polymeric immunoglobulin receptor
- Secretory IgA
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases