TY - JOUR
T1 - Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and alzheimer disease in a transgenic mouse model and human samples
AU - Tai, Leon M.
AU - Bilousova, Tina
AU - Jungbauer, Lisa
AU - Roeske, Stephen K.
AU - Youmans, Katherine L.
AU - Yu, Chunjiang
AU - Poon, Wayne W.
AU - Cornwell, Lindsey B.
AU - Miller, Carol A.
AU - Vinters, Harry V.
AU - Van Eldik, Linda J.
AU - Fardo, David W.
AU - Estus, Steve
AU - Bu, Guojun
AU - Gylys, Karen Hoppens
AU - LaDu, Mary Jo
PY - 2013/2/22
Y1 - 2013/2/22
N2 - Background: An ELISA was developed to determine the role of apoE/Aβ on soluble Aβ accumulation. Results: In AD transgenic mouse brain and human synaptosomes and CSF, levels of soluble apoE/Aβ are lower and oligomeric Aβ levels are higher with APOE4 and AD. Conclusion: Isoform-specific apoE/Aβ levels modulate soluble oligomeric Aβ levels. Significance: ApoE/Aβ and oligomeric Aβ represent a mechanistic approach to AD biomarkers.
AB - Background: An ELISA was developed to determine the role of apoE/Aβ on soluble Aβ accumulation. Results: In AD transgenic mouse brain and human synaptosomes and CSF, levels of soluble apoE/Aβ are lower and oligomeric Aβ levels are higher with APOE4 and AD. Conclusion: Isoform-specific apoE/Aβ levels modulate soluble oligomeric Aβ levels. Significance: ApoE/Aβ and oligomeric Aβ represent a mechanistic approach to AD biomarkers.
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U2 - 10.1074/jbc.M112.442103
DO - 10.1074/jbc.M112.442103
M3 - Article
C2 - 23293020
AN - SCOPUS:84874334207
SN - 0021-9258
VL - 288
SP - 5914
EP - 5926
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 8
ER -
