Leveraging Plasma Membrane Repair Therapeutics for Treating Neurodegenerative Diseases

Hannah R. Bulgart, Isabella Goncalves, Noah Weisleder

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Plasma membrane repair is an essential cellular mechanism that reseals membrane disruptions after a variety of insults, and compromised repair capacity can contribute to the progression of many diseases. Neurodegenerative diseases are marked by membrane damage from many sources, reduced membrane integrity, elevated intracellular calcium concentrations, enhanced reactive oxygen species production, mitochondrial dysfunction, and widespread neuronal death. While the toxic intracellular effects of these changes in cellular physiology have been defined, the specific mechanism of neuronal death in certain neurodegenerative diseases remains unclear. An abundance of recent evidence indicates that neuronal membrane damage and pore formation in the membrane are key contributors to neurodegenerative disease pathogenesis. In this review, we have outlined evidence supporting the hypothesis that membrane damage is a contributor to neurodegenerative diseases and that therapeutically enhancing membrane repair can potentially combat neuronal death.

Original languageEnglish
Article number1660
JournalCells
Volume12
Issue number12
DOIs
StatePublished - Jun 2023

Bibliographical note

Publisher Copyright:
© 2023 by the authors.

Funding

This research was supported by the National Institutes of Health’s National Institute on Aging, grant R01-AG056504. This content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health’s National Institute on Aging.

FundersFunder number
National Institutes of Health (NIH)
National Institute on AgingR01-AG056504
National Institute on Aging

    Keywords

    • Alzheimer’s Disease
    • membrane repair
    • neurodegeneration
    • Parkinson’s Disease

    ASJC Scopus subject areas

    • General Biochemistry, Genetics and Molecular Biology

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