TY - JOUR
T1 - Lifetime Body Weight Trajectories and Risk of Renal Cell Cancer
T2 - A Large U.S. Prospective Cohort Study
AU - Deng, Zhengyi
AU - Hajihosseini, Morteza
AU - Moore, Justin X.
AU - Khan, Saira
AU - Graff, Rebecca E.
AU - Bondy, Melissa L.
AU - Chung, Benjamin I.
AU - Langston, Marvin E.
N1 - Publisher Copyright:
© 2023 American Association for Cancer Research.
PY - 2023/11/1
Y1 - 2023/11/1
N2 - Background: Body mass index (BMI) is a known risk factor for renal cell cancer (RCC), but data are limited as to the effect of lifetime exposure to excess body weight. Methods: Using the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (N = 138,614, 527 incident RCCs), we identified several anthropometric measures to capture the lifetime BMI patterns: (i) BMI at specific ages; (ii) adulthood BMI trajectories; (iii) cumulative exposure to overweight/obesity denoted as weighted years of living overweight/obese (WYO); and (iv) weight change during each age span. We conducted multivariable Cox model to quantify the association between each anthropometric metric and incident RCC. Results: A higher BMI at ages 20 and 50 and at baseline was associated with a greater hazard of RCC. Compared with individuals who retained normal BMI throughout adulthood, we observed an increased hazard of RCC for BMI trajectory of progressing from normal BMI to overweight [HR, 1.49; 95% confidence interval (CI), 1.19–1.87], from normal BMI to obesity (HR, 2.22; 95% CI, 1.70–2.90), and from overweight to obesity (HR, 2.78; 95% CI, 1.81–4.27). Compared with individuals who were never overweight (WYO = 0), elevated HRs were observed among individuals who experienced low (HR, 1.31; 95% CI, 0.99–1.74), medium (HR, 1.57; 95% CI, 1.20–2.05), and high (HR, 2.10; 95% CI, 1.62–2.72) WYO tertile. Weight gain of ≥10 kg was associated with increased RCC incidence for each age span. Conclusions: Across the lifespan, being overweight/obese, weight gain, and higher cumulative exposure to excess weight were all associated with increased RCC risk. Impact: It is important to avoid weight gain and assess BMI from a life-course perspective to reduce RCC risk.
AB - Background: Body mass index (BMI) is a known risk factor for renal cell cancer (RCC), but data are limited as to the effect of lifetime exposure to excess body weight. Methods: Using the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (N = 138,614, 527 incident RCCs), we identified several anthropometric measures to capture the lifetime BMI patterns: (i) BMI at specific ages; (ii) adulthood BMI trajectories; (iii) cumulative exposure to overweight/obesity denoted as weighted years of living overweight/obese (WYO); and (iv) weight change during each age span. We conducted multivariable Cox model to quantify the association between each anthropometric metric and incident RCC. Results: A higher BMI at ages 20 and 50 and at baseline was associated with a greater hazard of RCC. Compared with individuals who retained normal BMI throughout adulthood, we observed an increased hazard of RCC for BMI trajectory of progressing from normal BMI to overweight [HR, 1.49; 95% confidence interval (CI), 1.19–1.87], from normal BMI to obesity (HR, 2.22; 95% CI, 1.70–2.90), and from overweight to obesity (HR, 2.78; 95% CI, 1.81–4.27). Compared with individuals who were never overweight (WYO = 0), elevated HRs were observed among individuals who experienced low (HR, 1.31; 95% CI, 0.99–1.74), medium (HR, 1.57; 95% CI, 1.20–2.05), and high (HR, 2.10; 95% CI, 1.62–2.72) WYO tertile. Weight gain of ≥10 kg was associated with increased RCC incidence for each age span. Conclusions: Across the lifespan, being overweight/obese, weight gain, and higher cumulative exposure to excess weight were all associated with increased RCC risk. Impact: It is important to avoid weight gain and assess BMI from a life-course perspective to reduce RCC risk.
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U2 - 10.1158/1055-9965.EPI-23-0668
DO - 10.1158/1055-9965.EPI-23-0668
M3 - Article
C2 - 37624040
AN - SCOPUS:85175742276
SN - 1055-9965
VL - 32
SP - 1651
EP - 1659
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 11
ER -