Light-activated ruthenium complexes photobind DNA and are cytotoxic in the photodynamic therapy window

Erin Wachter; David K. Heidary; Brock S. Howerton; Sean Parkin; Edith C. Glazer

doi:10.1039/c2cc33359g

Light-activated ruthenium complexes photobind DNA and are cytotoxic in the photodynamic therapy window

Erin Wachter, David K. Heidary, Brock S. Howerton, Sean Parkin, Edith C. Glazer

Chemistry

Research output: Contribution to journal › Article › peer-review

293 Scopus citations

Abstract

Incorporation of biquinoline ligands into Ru(II) polypyridyl complexes produces light-activated systems that eject a ligand and photobind DNA after irradiation with visible and near-IR light. Structural analysis shows that distortion facilitates the photochemistry, and gel shift and cytotoxicity studies prove the compounds act as anti-cancer photodynamic therapy (PDT) agents in the tissue penetrant region.

Original language	English
Pages (from-to)	9649-9651
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	77
DOIs	https://doi.org/10.1039/c2cc33359g
State	Published - Aug 29 2012

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/c2cc33359g

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abstract = "Incorporation of biquinoline ligands into Ru(II) polypyridyl complexes produces light-activated systems that eject a ligand and photobind DNA after irradiation with visible and near-IR light. Structural analysis shows that distortion facilitates the photochemistry, and gel shift and cytotoxicity studies prove the compounds act as anti-cancer photodynamic therapy (PDT) agents in the tissue penetrant region.",

author = "Erin Wachter and Heidary, \{David K.\} and Howerton, \{Brock S.\} and Sean Parkin and Glazer, \{Edith C.\}",

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AU - Wachter, Erin

AU - Heidary, David K.

AU - Howerton, Brock S.

AU - Parkin, Sean

AU - Glazer, Edith C.

PY - 2012/8/29

Y1 - 2012/8/29

N2 - Incorporation of biquinoline ligands into Ru(II) polypyridyl complexes produces light-activated systems that eject a ligand and photobind DNA after irradiation with visible and near-IR light. Structural analysis shows that distortion facilitates the photochemistry, and gel shift and cytotoxicity studies prove the compounds act as anti-cancer photodynamic therapy (PDT) agents in the tissue penetrant region.

AB - Incorporation of biquinoline ligands into Ru(II) polypyridyl complexes produces light-activated systems that eject a ligand and photobind DNA after irradiation with visible and near-IR light. Structural analysis shows that distortion facilitates the photochemistry, and gel shift and cytotoxicity studies prove the compounds act as anti-cancer photodynamic therapy (PDT) agents in the tissue penetrant region.

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Light-activated ruthenium complexes photobind DNA and are cytotoxic in the photodynamic therapy window

Abstract

ASJC Scopus subject areas

UN SDGs

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