Knowledge on brain networks subserving vocalization in vocally healthy individuals under various task conditions is scarce but paramount to understand voice disorders. The aims of our study were to determine (1) the effect of social-evaluative stress on the central neural control of phonation underlying speech production; and (2) the neural signature, personality profile, and aerodynamic vocal function in relation to salivary cortisol responses. Thirteen vocally healthy females underwent an event-related sparse-sampling fMRI protocol consisting of voiced and whispered sentence productions with and without exposure to the social-evaluative stressor public speaking anticipation. Participants completed a personality questionnaire, rating scales of negative emotional state, and provided salivary cortisol samples. In the total sample, the task contrast of voiced productions revealed that stressor exposure resulted in a peak activation in the right caudate with concomitant deactivations in the bilateral pgACC and aMCC, and right IFG, BA 9, BA 10, insula, putamen, and thalamus. There were individual differences in stressor-induced brain activations as a function of stress reactivity with greater cortisol reactivity linked with lower laryngeal motor cortex activity and lower scores on aspects of extraversion. Our data confirm that stress alters the phonatory control for speech production through limbic-motor interactions. The findings support the Trait Theory of Voice Disorders (Roy and Bless 2000) and help provide critical insights to the study of voice disorders such as primary muscle tension dysphonia.
|Number of pages||18|
|Journal||Brain Imaging and Behavior|
|State||Published - Oct 1 2020|
Bibliographical noteFunding Information:
Funding This work was supported by the National Center for Research Resources and the National Center for Advancing Translational Sciences [grant number UL1TR001998]; Center for Clinical and Translational Science Pilot Research Program, University of Kentucky; and the Magnetic Resonance Imaging and Spectroscopy Center Pilot Research Program, University of Kentucky.
© 2019, The Author(s).
- Functional MRI
- Muscle tension dysphonia
- Voice disorders
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Clinical Neurology
- Cognitive Neuroscience
- Cellular and Molecular Neuroscience
- Psychiatry and Mental health
- Behavioral Neuroscience