Abstract
The emergence of multidrug-resistant bacteria as the cause of ventriculoperitoneal shunt infections is a disconcerting phenomenon that often requires the use of alternative antimicrobials due to resistance against commonly used agents. The following is a case report describing the successful treatment of a ventriculoperitoneal shunt infection caused by a heteroresistant strain of Staphylococcus aureus with linezolid. Linezolid may have utility in treating pediatric CNS infections due to its tolerability, excellent blood-brain barrier penetration, and activity against multiple resistant Gram-positive organisms such as S. aureus, vancomycin-resistant Enterococcus faecium and Streptococcus pneumoniae.
| Original language | English |
|---|---|
| Pages (from-to) | 102-104 |
| Number of pages | 3 |
| Journal | Pediatric Neurosurgery |
| Volume | 41 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 2005 |
Keywords
- Gram-positive organisms
- Heteroresistance
- Linezolid
- Vancomycin
- Ventriculitis
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Surgery
- Clinical Neurology