Lipid Droplets in Neurodegenerative Disorders

Brandon C. Farmer, Adeline E. Walsh, Jude C. Kluemper, Lance A. Johnson

Research output: Contribution to journalReview articlepeer-review

94 Scopus citations


Knowledge of lipid droplets (LDs) has evolved from simple depots of lipid storage to dynamic and functionally active organelles involved in a variety of cellular functions. Studies have now informed significant roles for LDs in cellular signaling, metabolic disease, and inflammation. While lipid droplet biology has been well explored in peripheral organs such as the liver and heart, LDs within the brain are relatively understudied. The presence and function of these dynamic organelles in the central nervous system has recently gained attention, especially in the context of neurodegeneration. In this review, we summarize the current understanding of LDs within the brain, with an emphasis on their relevance in neurodegenerative diseases.

Original languageEnglish
Article number742
JournalFrontiers in Neuroscience
StatePublished - Jul 29 2020

Bibliographical note

Funding Information:
This work was supported by the National Institute on Aging (BF – F30AG06342201A, LJ - 1R01AG060056-01, and R01AG060056-02), and the National Institute of General Medical Sciences (LJCOBRE P20 GM103527)

Publisher Copyright:
© Copyright © 2020 Farmer, Walsh, Kluemper and Johnson.


  • CNS
  • astrocytes
  • brain
  • fatty acids
  • lipid droplet
  • microglia
  • neurodegeneration

ASJC Scopus subject areas

  • Neuroscience (all)


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