Lipid Droplets in Neurodegenerative Disorders

Brandon C. Farmer; Adeline E. Walsh; Jude C. Kluemper; Lance A. Johnson

doi:10.3389/fnins.2020.00742

Lipid Droplets in Neurodegenerative Disorders

Brandon C. Farmer, Adeline E. Walsh, Jude C. Kluemper, Lance A. Johnson

Research output: Contribution to journal › Review article › peer-review

182 Scopus citations

Abstract

Knowledge of lipid droplets (LDs) has evolved from simple depots of lipid storage to dynamic and functionally active organelles involved in a variety of cellular functions. Studies have now informed significant roles for LDs in cellular signaling, metabolic disease, and inflammation. While lipid droplet biology has been well explored in peripheral organs such as the liver and heart, LDs within the brain are relatively understudied. The presence and function of these dynamic organelles in the central nervous system has recently gained attention, especially in the context of neurodegeneration. In this review, we summarize the current understanding of LDs within the brain, with an emphasis on their relevance in neurodegenerative diseases.

Original language	English
Article number	742
Journal	Frontiers in Neuroscience
Volume	14
DOIs	https://doi.org/10.3389/fnins.2020.00742
State	Published - Jul 29 2020

Bibliographical note

Publisher Copyright:
© Copyright © 2020 Farmer, Walsh, Kluemper and Johnson.

Funding

This work was supported by the National Institute on Aging (BF – F30AG06342201A, LJ - 1R01AG060056-01, and R01AG060056-02), and the National Institute of General Medical Sciences (LJCOBRE P20 GM103527)

Funders	Funder number
LJCOBRE	P20 GM103527
National Institute on Aging	BF – F30AG06342201A, R01AG060056-02
National Institute of General Medical Sciences DP2GM119177 Sophie Dumont National Institute of General Medical Sciences

Keywords

CNS
astrocytes
brain
fatty acids
lipid droplet
microglia
neurodegeneration

ASJC Scopus subject areas

General Neuroscience

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10.3389/fnins.2020.00742

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abstract = "Knowledge of lipid droplets (LDs) has evolved from simple depots of lipid storage to dynamic and functionally active organelles involved in a variety of cellular functions. Studies have now informed significant roles for LDs in cellular signaling, metabolic disease, and inflammation. While lipid droplet biology has been well explored in peripheral organs such as the liver and heart, LDs within the brain are relatively understudied. The presence and function of these dynamic organelles in the central nervous system has recently gained attention, especially in the context of neurodegeneration. In this review, we summarize the current understanding of LDs within the brain, with an emphasis on their relevance in neurodegenerative diseases.",

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AU - Walsh, Adeline E.

AU - Kluemper, Jude C.

AU - Johnson, Lance A.

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Y1 - 2020/7/29

N2 - Knowledge of lipid droplets (LDs) has evolved from simple depots of lipid storage to dynamic and functionally active organelles involved in a variety of cellular functions. Studies have now informed significant roles for LDs in cellular signaling, metabolic disease, and inflammation. While lipid droplet biology has been well explored in peripheral organs such as the liver and heart, LDs within the brain are relatively understudied. The presence and function of these dynamic organelles in the central nervous system has recently gained attention, especially in the context of neurodegeneration. In this review, we summarize the current understanding of LDs within the brain, with an emphasis on their relevance in neurodegenerative diseases.

AB - Knowledge of lipid droplets (LDs) has evolved from simple depots of lipid storage to dynamic and functionally active organelles involved in a variety of cellular functions. Studies have now informed significant roles for LDs in cellular signaling, metabolic disease, and inflammation. While lipid droplet biology has been well explored in peripheral organs such as the liver and heart, LDs within the brain are relatively understudied. The presence and function of these dynamic organelles in the central nervous system has recently gained attention, especially in the context of neurodegeneration. In this review, we summarize the current understanding of LDs within the brain, with an emphasis on their relevance in neurodegenerative diseases.

KW - CNS

KW - astrocytes

KW - brain

KW - fatty acids

KW - lipid droplet

KW - microglia

KW - neurodegeneration

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Lipid Droplets in Neurodegenerative Disorders

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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