Lipid peroxidation and protein oxidation in Alzheimer's disease brain: Potential causes and consequences involving amyloid β-peptide-associated free radical oxidative stress

D. Allan Butterfield, Christopher M. Lauderback

Research output: Contribution to journalArticlepeer-review

906 Scopus citations

Abstract

Amyloid β-peptide (Aβ) is heavily deposited in the brains of Alzheimer's disease (AD) patients, and free radical oxidative stress, particularly of neuronal lipids and proteins, is extensive. Recent research suggests that these two observations may be linked by Aβ-induced oxidative stress in AD brain. This review summarizes current knowledge on phospholipid peroxidation and protein oxidation in AD brain, one potential cause of this oxidative stress, and consequences of Aβ-induced lipid peroxidation and protein oxidation in AD brain.

Original languageEnglish
Pages (from-to)1050-1060
Number of pages11
JournalFree Radical Biology and Medicine
Volume32
Issue number11
DOIs
StatePublished - Jun 1 2002

Bibliographical note

Funding Information:
This work was supported in part by National Institutes of Health grants to D.A.B.

Keywords

  • Amyloid β-peptide
  • Free radicals
  • Lipid peroxidation
  • Neurotoxicity
  • Protein oxidation

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)

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