Lipid peroxidation and protein oxidation in Alzheimer's disease brain: Potential causes and consequences involving amyloid β-peptide-associated free radical oxidative stress

D. Allan Butterfield; Christopher M. Lauderback

doi:10.1016/S0891-5849(02)00794-3

Lipid peroxidation and protein oxidation in Alzheimer's disease brain: Potential causes and consequences involving amyloid β-peptide-associated free radical oxidative stress

D. Allan Butterfield, Christopher M. Lauderback

Research output: Contribution to journal › Article › peer-review

916 Citations (SciVal)

Abstract

Amyloid β-peptide (Aβ) is heavily deposited in the brains of Alzheimer's disease (AD) patients, and free radical oxidative stress, particularly of neuronal lipids and proteins, is extensive. Recent research suggests that these two observations may be linked by Aβ-induced oxidative stress in AD brain. This review summarizes current knowledge on phospholipid peroxidation and protein oxidation in AD brain, one potential cause of this oxidative stress, and consequences of Aβ-induced lipid peroxidation and protein oxidation in AD brain.

Original language	English
Pages (from-to)	1050-1060
Number of pages	11
Journal	Free Radical Biology and Medicine
Volume	32
Issue number	11
DOIs	https://doi.org/10.1016/S0891-5849(02)00794-3
State	Published - Jun 1 2002

Bibliographical note

Funding Information:
This work was supported in part by National Institutes of Health grants to D.A.B.

Keywords

Amyloid β-peptide
Free radicals
Lipid peroxidation
Neurotoxicity
Protein oxidation

ASJC Scopus subject areas

Biochemistry
Physiology (medical)

Access to Document

10.1016/S0891-5849(02)00794-3

Cite this

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abstract = "Amyloid β-peptide (Aβ) is heavily deposited in the brains of Alzheimer's disease (AD) patients, and free radical oxidative stress, particularly of neuronal lipids and proteins, is extensive. Recent research suggests that these two observations may be linked by Aβ-induced oxidative stress in AD brain. This review summarizes current knowledge on phospholipid peroxidation and protein oxidation in AD brain, one potential cause of this oxidative stress, and consequences of Aβ-induced lipid peroxidation and protein oxidation in AD brain.",

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Lipid peroxidation and protein oxidation in Alzheimer's disease brain: Potential causes and consequences involving amyloid β-peptide-associated free radical oxidative stress. / Butterfield, D. Allan; Lauderback, Christopher M.
In: Free Radical Biology and Medicine, Vol. 32, No. 11, 01.06.2002, p. 1050-1060.

Research output: Contribution to journal › Article › peer-review

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KW - Free radicals

KW - Lipid peroxidation

KW - Neurotoxicity

KW - Protein oxidation

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Lipid peroxidation and protein oxidation in Alzheimer's disease brain: Potential causes and consequences involving amyloid β-peptide-associated free radical oxidative stress

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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