Lipid peroxidation in brain or spinal cord mitochondria after injury

Edward D. Hall, Juan A. Wang, Jeffrey M. Bosken, Indrapal N. Singh

Research output: Contribution to journalArticlepeer-review

75 Scopus citations

Abstract

Extensive evidence has demonstrated an important role of oxygen radical formation (i.e., oxidative stress) as a mediator of the secondary injury process that occurs following primary mechanical injury to the brain or spinal cord. The predominant form of oxygen radical-induced oxidative damage that occurs in injured nervous tissue is lipid peroxidation (LP). Much of the oxidative stress in injured nerve cells initially begins in mitochondria via the generation of the reactive nitrogen species peroxynitrite (PN) which then can generate multiple highly reactive free radicals including nitrogen dioxide (•NO2), hydroxyl radical (•OH) and carbonate radical (•CO3). Each can readily induce LP within the phospholipid membranes of the mitochondrion leading to respiratory dysfunction, calcium buffering impairment, mitochondrial permeability transition and cell death. Validation of the role of LP in central nervous system secondary injury has been provided by the mitochondrial and neuroprotective effects of multiple antioxidant agents which are briefly reviewed.

Original languageEnglish
Pages (from-to)169-174
Number of pages6
JournalJournal of Bioenergetics and Biomembranes
Volume48
Issue number2
DOIs
StatePublished - Apr 1 2016

Bibliographical note

Funding Information:
The research described in the authors' laboratory was partially funded by grants from the National Institute of Neurological Disorders & Stroke (NINDS) including R01 NS046566, R01 NS083405, R01 NS084857, P01 NS058484, R21 NS077434 and P30 NS051220 and grants from the Kentucky Spinal Cord & Head Injury Research Trust.

Funding Information:
The research described in the authors’ laboratory was partially funded by grants from the National Institute of Neurological Disorders & Stroke (NINDS) including R01 NS046566, R01 NS083405, R01 NS084857, P01 NS058484, R21 NS077434 and P30 NS051220 and grants from the Kentucky Spinal Cord & Head Injury Research Trust.

Publisher Copyright:
© 2015, Springer Science+Business Media New York.

Keywords

  • Antioxidant
  • Lipid peroxidation
  • Mitochondria
  • Oxidative stress
  • Spinal cord injury
  • Traumatic brain injury

ASJC Scopus subject areas

  • Physiology
  • Cell Biology

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