Lipid peroxidation is an early event in the brain in amnestic mild cognitive impairment

William R. Markesbery, Richard J. Kryscio, Mark A. Lovell, Jason D. Morrow

Research output: Contribution to journalArticlepeer-review

257 Scopus citations


Multiple studies demonstrate that the brain in Alzheimer's disease (AD) contains extensive oxidative damage. Most of these studies used advanced-stage AD patients raising the question of whether oxidative damage is a late effect of neurodegeneration or precedes and contributes to the pathogenesis of AD. Here we describe F2-isoprostane (F2-IsoP) and F 4-neuroprostane (F4-NP) levels in longitudinally followed, well documented autopsied normal control subjects and patients with amnestic mild cognitive impairment (MCI), and late-stage AD. Gas chromatography/negative ion chemical ionization/mass spectrometry was used to determine F 2-IsoP and F4-NP levels. Significant increases in F 2-IsoP levels were found in frontal, parietal and occipital lobes in MCI and late AD compared to controls but no significant differences were present between MCI and late AD. A significant increase in F4-NPs was present in parietal and occipital lobes in MCI compared to controls and a significant increase was present in these regions and hippocampus in late AD compared to controls. The only difference betwen MCI and late AD was significantly increased F4-NP in hippocampus in late AD. Our data indicate that lipid peroxidation is present in the brain of MCI patients and suggest that oxidative damage may play a role in the patliogenesis of AD.

Original languageEnglish
Pages (from-to)730-735
Number of pages6
JournalAnnals of Neurology
Issue number5
StatePublished - Nov 2005

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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