Lipopolysaccharide increases ambient temperature preference in C57BL/6J adult mice

Chana Akins, Del Thiessen, Robert Cocke

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


The hypothesis was tested that animals exposed to a potentially dangerous endotoxin would attempt to behaviorally elevate their body temperature, perhaps in an effort to engage those immunological mechanisms which would counter the adverse effects of the endotoxin. Lipopolysaccharide (LPS) from Escherichia coli injected subcutaneously (100 μg) in adult C57BL/6J mice increased gradient temperature preference by 2.4°C over saline controls. The increase in body temperature of 1.1°C after LPS injection was due to the preference for higher ambient temperatures and was not the result of a systemic reaction to LPS (animals not exposed to the gradient did not differ in body temperature). In summary, our data indicate that adult mice self-induce a febrile response, perhaps as an attempt to compensate for the physiological impact of the endotoxin.

Original languageEnglish
Pages (from-to)461-463
Number of pages3
JournalPhysiology and Behavior
Issue number2
StatePublished - Aug 1991


  • Body temperature
  • C57Bl/6J mice
  • Lipopolysaccharide
  • Temperature preference

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience


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