Lipoprotein-matrix interactions in macrovascular disease in diabetes

Lisa R. Tannock, Alan Chait

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations


The retention of atherogenic lipoproteins in the artery wall through their interactions with the arterial extracellular matrix is a critical step in the development of atherosclerosis, as outlined in the 'response to retention' hypothesis. Lipoprotein retention by vascular proteoglycans is thought to be the principle means of lipoprotein retention, although lipoprotein binding to other components of the extracellular matrix has been reported. The interactions of lipoproteins and proteoglycans can be direct through ionic interactions between the negatively charged glycosaminoglycan chains of proteoglycans and positively charged residues of apolipoproteins B and E, or can be mediated through bridging molecules such as lipoprotein lipase. Retention of atherogenic lipoproteins within the artery wall environment leads to pathophysiologically important modifications of the lipoproteins, including oxidation. Oxidation of lipoproteins leads to increased uptake by macrophages, leading to the formation of foam cells. This article reviews the scientific evidence in support of the response to retention hypothesis, with a specific focus on the effects of diabetes to modify lipoprotein retention.

Original languageEnglish
Pages (from-to)1728-1742
Number of pages15
JournalFrontiers in Bioscience
StatePublished - 2004


  • Atherosclerosis
  • Binding
  • Diabetes
  • Extracellular matrix
  • Glycosaminoglycans
  • Lipoproteins
  • Proteoglycans
  • Review

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology (all)
  • Immunology and Microbiology (all)


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