Listeria monocytogenes

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Listeria monocytogenes typically causes infection in humans when ready-to-eat food products are contaminated during processing; the bacteria increase in number during refrigerated storage, and then the food is consumed without adequate heating. L. monocytogenes is a nonspore-forming, Gram-positive bacillus that is readily found in both soil and water samples. It mediates its own uptake into nonphagocytic cells via a family of surface-exposed proteins called internalins. Orally transmitted models of L. monocytogenes infection have not been as widely used as intravenous or intraperitoneal models due to a high degree of innate resistance in many species and significant phenotypic variability among infected animals. Recent improvements, particularly for the mouse model, have greatly improved the efficiency of intestinal infection following oral transmission, and the use of a standardized model would help to greatly advance the field. Studies that directly compare infections in young versus aged animals may shed light on potential therapeutic strategies that could prevent these deadly infections.

Original languageEnglish
Title of host publicationLaboratory Models for Foodborne Infections
Pages185-196
Number of pages12
ISBN (Electronic)9781498721684
DOIs
StatePublished - Jan 1 2017

Bibliographical note

Publisher Copyright:
© 2017 by Taylor and Francis Group, LLC.

ASJC Scopus subject areas

  • Engineering (all)
  • Agricultural and Biological Sciences (all)

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