Liver transplantation for the treatment of liver metastases from neuroendocrine tumors: An analysis of the UNOS database

Roberto Gedaly, Michael F. Daily, Daniel Davenport, Patrick P. McHugh, Alvaro Koch, Paul Angulo, Jonathan C. Hundley

Research output: Contribution to journalArticlepeer-review

143 Scopus citations


Objective: To determine outcomes in patients undergoing liver transplantation (LT) for metastatic neuroendocrine tumors (NETs). Design: Retrospective analysis. Setting: University of Kentucky Medical Center. Patients: Patients undergoing LT performed for NET metastases from October 1, 1988, through January 31, 2008, were analyzed using the United Network for Organ Sharing database. Main Outcome Measure: Patient survival. Results: During the study period, 87 280 LTs were performed. One hundred fifty LTs were performed for metastatic NETs. Among those 150 patients undergoing LT, 51 patients (34.0%) had carcinoid, 6 had insulinoma (4.0%), 3 had glucagonoma (2.0%), 11 had gastrinoma (7.3%), AND 9 had vasoactive intestinal peptide-secreting tumors (6.0%); an additional 70 (46.7%) had an unspecified NET. The mean (SE) age of the patients was 45.1 (12.5) years. The mean (SE) cold ischemic time was 8.9 (4.1) hours. One hundred forty-four patients were adults and 6 were children. Thirteen patients received another organ at the time of LT. During the same period, 4693 patients underwent transplantation for hepatocellular carcinoma. Overall, 1-, 3-, and 5-year survival rates for patients with NETs undergoing isolated LT were 81%, 65%, and 49%, respectively. No difference in survival was observed in patients with carcinoid vs noncarcinoid tumors (P=.84). No significant difference was observed in patient survival between those with metastatic NETs and those with hepatocellular carcinoma. Patients waiting for LT longer than 2 months had improved survival (P=.005). Conclusions: Patients with liver metastases from NETs who were undergoing LT had long-term survival similar to that of patients with hepatocellular carcinoma. Longer wait times were associated with better outcomes in our series. Waiting for Disease to stabilize before considering patients with liver metastases from NETs for transplantation may be appropriate. Excellent results can be obtained in highly selected patients.

Original languageEnglish
Pages (from-to)953-958
Number of pages6
JournalArchives of Surgery
Issue number8
StatePublished - Aug 2011

ASJC Scopus subject areas

  • Surgery


Dive into the research topics of 'Liver transplantation for the treatment of liver metastases from neuroendocrine tumors: An analysis of the UNOS database'. Together they form a unique fingerprint.

Cite this