Lobeline, a nicotinic partial agonist attenuates alcohol consumption and preference in male C57BL/6J mice

Justin M. Farook, Ben Lewis, Justin G. Gaddis, John M. Littleton, Susan Barron

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Lobeline is a partial nicotinic agonist and is currently being investigated as a therapeutic drug for several addictive disorders particularly for smoking cessation. The present study evaluated the effects of repeated (continuous and recurring) administration of lobeline on alcohol consumption (10% alcohol vs. water) and alcohol preference using a 2-bottle choice test procedure. Male C57BL/6J mice were individually housed and acclimatized to 10% alcohol. Immediately following the last day of alcohol acclimatization and attainment of consistent drinking pattern, mice (n = 5/group) received subcutaneous injections of lobeline (3, 5, or 10 mg/kg) or saline. Groups received either repeated-recurring (3 injections, given every other day) or repeated-continuous (daily injections for 5 days) subcutaneous injections of lobeline. Fluid consumption (alcohol and water) was recorded daily. Results showed that lobeline significantly reduced alcohol consumption and alcohol preference during the repeated (recurring and continuous) administration phases, while total fluid consumption remained unchanged. These results provide support that nicotinic receptor based drugs may be useful as potential treatments for alcoholism.

Original languageEnglish
Pages (from-to)503-506
Number of pages4
JournalPhysiology and Behavior
Issue number3-4
StatePublished - Jun 22 2009

Bibliographical note

Funding Information:
This research was supported in part by a petite grant awarded to J.M. Farook from the Center on Drug and Alcohol Research, University of Kentucky, and supplemented by a NIAAA grant awarded to J.M. Littleton (#12600). We thank Noel R. Monks, PhD (Naprogenix, Inc) for a valuable critique of this manuscript.


  • Acetylcholine receptors
  • Alcohol
  • C57BL/6J mice
  • Consumption
  • Nicotine

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience


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