TY - JOUR
T1 - Lobeline Effects on Cognitive Performance in Adult ADHD
AU - Martin, Catherine A.
AU - Nuzzo, Paul A.
AU - Ranseen, John D.
AU - Kleven, Mark S.
AU - Guenthner, Greg
AU - Williams, Yolanda
AU - Walsh, Sharon L.
AU - Dwoskin, Linda P.
N1 - Publisher Copyright:
© The Author(s) 2013.
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Objective: In preclinical studies, lobeline inhibited hyperactivity induced by nicotine and amphetamine, and improved performance and learning in studies utilizing radial-arm maze and spatial-discrimination water maze. This laboratory proof-of-concept study investigated lobeline as a treatment for ADHD symptoms in adults (31.11 ± 7.08 years). Method: Using cognitive tasks and self-report measures, the effects of lobeline (0, 7.5, 15, or 30 mg, s.l.) and methylphenidate (0, 15, or 30 mg, p.o.) were assessed in nine volunteers with ADHD. Results: Evidence suggested that lobeline could modestly improve working memory in adults with ADHD, but no significant improvement in attention was observed. Lobeline administration was associated with mild adverse side effects (nausea). Conclusion: Further investigation of lobeline on working memory may be warranted.
AB - Objective: In preclinical studies, lobeline inhibited hyperactivity induced by nicotine and amphetamine, and improved performance and learning in studies utilizing radial-arm maze and spatial-discrimination water maze. This laboratory proof-of-concept study investigated lobeline as a treatment for ADHD symptoms in adults (31.11 ± 7.08 years). Method: Using cognitive tasks and self-report measures, the effects of lobeline (0, 7.5, 15, or 30 mg, s.l.) and methylphenidate (0, 15, or 30 mg, p.o.) were assessed in nine volunteers with ADHD. Results: Evidence suggested that lobeline could modestly improve working memory in adults with ADHD, but no significant improvement in attention was observed. Lobeline administration was associated with mild adverse side effects (nausea). Conclusion: Further investigation of lobeline on working memory may be warranted.
KW - ADHD
KW - lobeline
KW - methylphenidate
UR - http://www.scopus.com/inward/record.url?scp=84976557140&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84976557140&partnerID=8YFLogxK
U2 - 10.1177/1087054713497791
DO - 10.1177/1087054713497791
M3 - Article
C2 - 23966351
AN - SCOPUS:84976557140
SN - 1087-0547
VL - 22
SP - 1361
EP - 1366
JO - Journal of Attention Disorders
JF - Journal of Attention Disorders
IS - 14
ER -