Lobeline Effects on Cognitive Performance in Adult ADHD

Catherine A. Martin; Paul A. Nuzzo; John D. Ranseen; Mark S. Kleven; Greg Guenthner; Yolanda Williams; Sharon L. Walsh; Linda P. Dwoskin

doi:10.1177/1087054713497791

Lobeline Effects on Cognitive Performance in Adult ADHD

Catherine A. Martin, Paul A. Nuzzo, John D. Ranseen, Mark S. Kleven, Greg Guenthner, Yolanda Williams, Sharon L. Walsh, Linda P. Dwoskin

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Objective: In preclinical studies, lobeline inhibited hyperactivity induced by nicotine and amphetamine, and improved performance and learning in studies utilizing radial-arm maze and spatial-discrimination water maze. This laboratory proof-of-concept study investigated lobeline as a treatment for ADHD symptoms in adults (31.11 ± 7.08 years). Method: Using cognitive tasks and self-report measures, the effects of lobeline (0, 7.5, 15, or 30 mg, s.l.) and methylphenidate (0, 15, or 30 mg, p.o.) were assessed in nine volunteers with ADHD. Results: Evidence suggested that lobeline could modestly improve working memory in adults with ADHD, but no significant improvement in attention was observed. Lobeline administration was associated with mild adverse side effects (nausea). Conclusion: Further investigation of lobeline on working memory may be warranted.

Original language	English
Pages (from-to)	1361-1366
Number of pages	6
Journal	Journal of Attention Disorders
Volume	22
Issue number	14
DOIs	https://doi.org/10.1177/1087054713497791
State	Published - Dec 1 2018

Bibliographical note

Publisher Copyright:
© The Author(s) 2013.

Funding

Funders	Funder number
National Institute of Mental Health	R43MH081553

Keywords

ADHD
lobeline
methylphenidate

ASJC Scopus subject areas

Developmental and Educational Psychology
Clinical Psychology

Access to Document

10.1177/1087054713497791

Cite this

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title = "Lobeline Effects on Cognitive Performance in Adult ADHD",

abstract = "Objective: In preclinical studies, lobeline inhibited hyperactivity induced by nicotine and amphetamine, and improved performance and learning in studies utilizing radial-arm maze and spatial-discrimination water maze. This laboratory proof-of-concept study investigated lobeline as a treatment for ADHD symptoms in adults (31.11 ± 7.08 years). Method: Using cognitive tasks and self-report measures, the effects of lobeline (0, 7.5, 15, or 30 mg, s.l.) and methylphenidate (0, 15, or 30 mg, p.o.) were assessed in nine volunteers with ADHD. Results: Evidence suggested that lobeline could modestly improve working memory in adults with ADHD, but no significant improvement in attention was observed. Lobeline administration was associated with mild adverse side effects (nausea). Conclusion: Further investigation of lobeline on working memory may be warranted.",

keywords = "ADHD, lobeline, methylphenidate",

author = "Martin, {Catherine A.} and Nuzzo, {Paul A.} and Ranseen, {John D.} and Kleven, {Mark S.} and Greg Guenthner and Yolanda Williams and Walsh, {Sharon L.} and Dwoskin, {Linda P.}",

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AU - Martin, Catherine A.

AU - Nuzzo, Paul A.

AU - Ranseen, John D.

AU - Kleven, Mark S.

AU - Guenthner, Greg

AU - Williams, Yolanda

AU - Walsh, Sharon L.

AU - Dwoskin, Linda P.

N1 - Publisher Copyright: © The Author(s) 2013.

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Objective: In preclinical studies, lobeline inhibited hyperactivity induced by nicotine and amphetamine, and improved performance and learning in studies utilizing radial-arm maze and spatial-discrimination water maze. This laboratory proof-of-concept study investigated lobeline as a treatment for ADHD symptoms in adults (31.11 ± 7.08 years). Method: Using cognitive tasks and self-report measures, the effects of lobeline (0, 7.5, 15, or 30 mg, s.l.) and methylphenidate (0, 15, or 30 mg, p.o.) were assessed in nine volunteers with ADHD. Results: Evidence suggested that lobeline could modestly improve working memory in adults with ADHD, but no significant improvement in attention was observed. Lobeline administration was associated with mild adverse side effects (nausea). Conclusion: Further investigation of lobeline on working memory may be warranted.

AB - Objective: In preclinical studies, lobeline inhibited hyperactivity induced by nicotine and amphetamine, and improved performance and learning in studies utilizing radial-arm maze and spatial-discrimination water maze. This laboratory proof-of-concept study investigated lobeline as a treatment for ADHD symptoms in adults (31.11 ± 7.08 years). Method: Using cognitive tasks and self-report measures, the effects of lobeline (0, 7.5, 15, or 30 mg, s.l.) and methylphenidate (0, 15, or 30 mg, p.o.) were assessed in nine volunteers with ADHD. Results: Evidence suggested that lobeline could modestly improve working memory in adults with ADHD, but no significant improvement in attention was observed. Lobeline administration was associated with mild adverse side effects (nausea). Conclusion: Further investigation of lobeline on working memory may be warranted.

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Lobeline Effects on Cognitive Performance in Adult ADHD

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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