Local adipose tissue renin-angiotensin system

Lisa A. Cassis, Sara B. Police, Frederique Yiannikouris, Sean E. Thatcher

Research output: Contribution to journalReview articlepeer-review

170 Scopus citations

Abstract

A local renin-angiotensin system (RAS) has been proposed in adipocytes. Adipocytes are a suggested source of components of the RAS, with regulation of their production related to obesity-hypertension. Both angiotensin type 1 and 2 receptors have been localized to adipocytes. Angiotensin II has been demonstrated to regulate adipocyte growth and differentiation, lipid metabolism, and expression and release of adipokines and RAS components, and to promote oxidative stress. Differences in regional expression of RAS components in visceral versus subcutaneous adipose tissue have been suggested as a link between abdominal obesity and cardiovascular disease. Finally, several studies support antihypertensive efficacy of RAS blockade in patients with type 2 diabetes and obesity. Future studies should address the role of adipocyte-specific deficiency of RAS components to definitively determine the relevance of the adipose RAS to normal physiology and to the development of hypertension.

Original languageEnglish
Pages (from-to)93-98
Number of pages6
JournalCurrent Hypertension Reports
Volume10
Issue number2
DOIs
StatePublished - Apr 2008

ASJC Scopus subject areas

  • Internal Medicine

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