Local production of anti-Vibrio cholerae mucosal antibody in reproductive tract tissues after cholera

Edward T. Ryan; Emily A. Bridges; Thomas I. Crean; Kaniz Gausia; Jena D. Hamadani; Ayesha Aziz; Sarah Hawkes; Monira Begum; Jozef Bogaerts; Shah M. Faruque; Mohammed Abdus Salam; George J. Fuchs; Stephen B. Calderwood

doi:10.1086/322807

Local production of anti-Vibrio cholerae mucosal antibody in reproductive tract tissues after cholera

Edward T. Ryan, Emily A. Bridges, Thomas I. Crean, Kaniz Gausia, Jena D. Hamadani, Ayesha Aziz, Sarah Hawkes, Monira Begum, Jozef Bogaerts, Shah M. Faruque, Mohammed Abdus Salam, George J. Fuchs, Stephen B. Calderwood

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

To investigate whether intestinal presentation of an antigen by Vibrio cholerae, a noninvasive organism, could induce an anatomically distant mucosal immune response in reproductive tract tissues, the endocervical immune responses of women in Bangladesh were evaluated after cholera. Endocervical secretions were analyzed for secretory IgA (sIgA) antibody against the B subunit of cholera toxin (CtxB) in 9 women with cholera and 8 women with diarrhea caused by neither V. cholerae nor heat labile enterotoxin-producing Escherichia coli. Women infected with V. cholerae developed significant sIgA anti-CtxB responses in endocervical samples (P .02). Antibody subtype analysis of endocervical IgA was consistent with local mucosal production (P .001). Women with cholera did not develop sIgA anti-CtxB responses in serum. The ability to generate specific mucosal immune responses in reproductive tract tissues after intestinal presentation of antigen could facilitate development of vaccines effective against reproductive tract pathogens.

Original language	English
Pages (from-to)	643-647
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	184
Issue number	5
DOIs	https://doi.org/10.1086/322807
State	Published - Sep 1 2001

Bibliographical note

Funding Information:
Financial support: Warren-Whitman-Richardson Traveling Fellowship, Harvard Medical School (to E.T.R.); Aaron Diamond Fellowship in Medicine and Human Rights, Center for the Study of Society and Medicine, Columbia University College of Physicians and Surgeons (to E.T.R.); and National Institutes of Health (AI-01332 to E.T.R.; AI-40725 to S.B.C. and E.T.R.; and HD-39165 to S.B.C. and E.T.R.). The ICDDR, B: Centre for Health and Population Research is supported by countries that share its concern for health problems in developing countries. Current donors providing unrestricted support include aid agencies of the governments of Australia, Bangladesh, Belgium, Canada, Japan, the Kingdom of Saudi Arabia, The Netherlands, Sweden, Sri Lanka, Switzerland, the United Kingdom, and the United States and international organizations, including the United Nations Children’s Fund.

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1086/322807

Cite this

Ryan, E. T., Bridges, E. A., Crean, T. I., Gausia, K., Hamadani, J. D., Aziz, A., Hawkes, S., Begum, M., Bogaerts, J., Faruque, S. M., Salam, M. A., Fuchs, G. J., & Calderwood, S. B. (2001). Local production of anti-Vibrio cholerae mucosal antibody in reproductive tract tissues after cholera. Journal of Infectious Diseases, 184(5), 643-647. https://doi.org/10.1086/322807

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abstract = "To investigate whether intestinal presentation of an antigen by Vibrio cholerae, a noninvasive organism, could induce an anatomically distant mucosal immune response in reproductive tract tissues, the endocervical immune responses of women in Bangladesh were evaluated after cholera. Endocervical secretions were analyzed for secretory IgA (sIgA) antibody against the B subunit of cholera toxin (CtxB) in 9 women with cholera and 8 women with diarrhea caused by neither V. cholerae nor heat labile enterotoxin-producing Escherichia coli. Women infected with V. cholerae developed significant sIgA anti-CtxB responses in endocervical samples (P .02). Antibody subtype analysis of endocervical IgA was consistent with local mucosal production (P .001). Women with cholera did not develop sIgA anti-CtxB responses in serum. The ability to generate specific mucosal immune responses in reproductive tract tissues after intestinal presentation of antigen could facilitate development of vaccines effective against reproductive tract pathogens.",

author = "Ryan, {Edward T.} and Bridges, {Emily A.} and Crean, {Thomas I.} and Kaniz Gausia and Hamadani, {Jena D.} and Ayesha Aziz and Sarah Hawkes and Monira Begum and Jozef Bogaerts and Faruque, {Shah M.} and Salam, {Mohammed Abdus} and Fuchs, {George J.} and Calderwood, {Stephen B.}",

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AU - Hamadani, Jena D.

AU - Aziz, Ayesha

AU - Hawkes, Sarah

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AU - Bogaerts, Jozef

AU - Faruque, Shah M.

AU - Salam, Mohammed Abdus

AU - Fuchs, George J.

AU - Calderwood, Stephen B.

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N2 - To investigate whether intestinal presentation of an antigen by Vibrio cholerae, a noninvasive organism, could induce an anatomically distant mucosal immune response in reproductive tract tissues, the endocervical immune responses of women in Bangladesh were evaluated after cholera. Endocervical secretions were analyzed for secretory IgA (sIgA) antibody against the B subunit of cholera toxin (CtxB) in 9 women with cholera and 8 women with diarrhea caused by neither V. cholerae nor heat labile enterotoxin-producing Escherichia coli. Women infected with V. cholerae developed significant sIgA anti-CtxB responses in endocervical samples (P .02). Antibody subtype analysis of endocervical IgA was consistent with local mucosal production (P .001). Women with cholera did not develop sIgA anti-CtxB responses in serum. The ability to generate specific mucosal immune responses in reproductive tract tissues after intestinal presentation of antigen could facilitate development of vaccines effective against reproductive tract pathogens.

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Local production of anti-Vibrio cholerae mucosal antibody in reproductive tract tissues after cholera

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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