Locally advanced solitary fibrous tumour of the prostate

Eric Wahlstedt, Christopher Zhou, Sydney Strup, Joon Kyung Kim, Stephen E. Strup, Leonard Yenwong, Derek B. Allison, Patrick J. Hensley

Research output: Contribution to journalArticlepeer-review

Abstract

Solitary fibrous tumours (SFTs) are rare mesenchymal neoplasms composed of spindle cells, most often occurring in the pleura. SFTs arising from the prostate are exceptionally rare, with only around 40 cases reported in literature to date. We report a man in his 60s who was referred to our clinic for elevated prostate-specific antigen and presented with mild obstructive lower urinary tract and defecatory symptoms. Prostate needle-core biopsy revealed neoplastic spindle cells that strongly expressed CD34. Cross-sectional imaging demonstrated a 12 cm locally advanced heterogeneous prostate mass with intravesical extension and mass effect on the anterior rectum. Radical cystoprostatectomy with orthotopic neobladder reconstruction was performed, and the diagnosis of primary prostatic SFT was made based on histological characteristics and immunophenotyping. We present diagnostic, clinical management and prognostic considerations in patients with primary prostatic SFT.

Original languageEnglish
Article numbere257666
JournalBMJ Case Reports
Volume16
Issue number10
DOIs
StatePublished - Oct 17 2023

Bibliographical note

Publisher Copyright:
© 2023 BMJ Publishing Group. All rights reserved.

Keywords

  • Pathology
  • Prostate
  • Urological surgery
  • Urology

ASJC Scopus subject areas

  • General Medicine

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