Locus coeruleus lesions potentiate neurotoxic effects of MPTP in dopaminergic neurons of the substantia nigra

Guoying Bing, Yi Zhang, Yoshifumi Watanabe, Bruce S. McEwen, Eric A. Stone

Research output: Contribution to journalArticlepeer-review

90 Scopus citations

Abstract

The observation that Parkinson's disease (PD) is associated with locus coeruleus (LC) noradrenergic neuronal degeneration suggests that the LC noradrenergic system may be involved in the pathogenesis and natural progression of the destruction of the substantia nigra (SN) dopaminergic neurons in Parkinson's disease. The relationship of these two systems was examined by injection of subtoxic doses of MPTP into unilateral LC 6-hydroxydopamine (6-OHDA) lesioned mice. A significant loss of dopaminergic cells was only found in the SN on the side of the LC lesions. These results suggest that the LC may have protective effects on SN dopaminergic neurons.

Original languageEnglish
Pages (from-to)261-265
Number of pages5
JournalBrain Research
Volume668
Issue number1-2
DOIs
StatePublished - Dec 30 1994

Bibliographical note

Funding Information:
This work was partially supported by Grant MH 45265 and AFOSR F49620-92-J-0084.

Keywords

  • Dopamine
  • Locus ceruleus
  • MPTP
  • Norepinephrine
  • Parkinson's disease
  • Substantia nigra

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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