Locus coeruleus lesions potentiate neurotoxic effects of MPTP in dopaminergic neurons of the substantia nigra

Guoying Bing; Yi Zhang; Yoshifumi Watanabe; Bruce S. McEwen; Eric A. Stone

doi:10.1016/0006-8993(94)90534-7

Locus coeruleus lesions potentiate neurotoxic effects of MPTP in dopaminergic neurons of the substantia nigra

Guoying Bing, Yi Zhang, Yoshifumi Watanabe, Bruce S. McEwen, Eric A. Stone

Neuroscience

Research output: Contribution to journal › Article › peer-review

91 Scopus citations

Abstract

The observation that Parkinson's disease (PD) is associated with locus coeruleus (LC) noradrenergic neuronal degeneration suggests that the LC noradrenergic system may be involved in the pathogenesis and natural progression of the destruction of the substantia nigra (SN) dopaminergic neurons in Parkinson's disease. The relationship of these two systems was examined by injection of subtoxic doses of MPTP into unilateral LC 6-hydroxydopamine (6-OHDA) lesioned mice. A significant loss of dopaminergic cells was only found in the SN on the side of the LC lesions. These results suggest that the LC may have protective effects on SN dopaminergic neurons.

Original language	English
Pages (from-to)	261-265
Number of pages	5
Journal	Brain Research
Volume	668
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(94)90534-7
State	Published - Dec 30 1994

Bibliographical note

Funding Information:
This work was partially supported by Grant MH 45265 and AFOSR F49620-92-J-0084.

Keywords

Dopamine
Locus ceruleus
MPTP
Norepinephrine
Parkinson's disease
Substantia nigra

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(94)90534-7

Cite this

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title = "Locus coeruleus lesions potentiate neurotoxic effects of MPTP in dopaminergic neurons of the substantia nigra",

abstract = "The observation that Parkinson's disease (PD) is associated with locus coeruleus (LC) noradrenergic neuronal degeneration suggests that the LC noradrenergic system may be involved in the pathogenesis and natural progression of the destruction of the substantia nigra (SN) dopaminergic neurons in Parkinson's disease. The relationship of these two systems was examined by injection of subtoxic doses of MPTP into unilateral LC 6-hydroxydopamine (6-OHDA) lesioned mice. A significant loss of dopaminergic cells was only found in the SN on the side of the LC lesions. These results suggest that the LC may have protective effects on SN dopaminergic neurons.",

keywords = "Dopamine, Locus ceruleus, MPTP, Norepinephrine, Parkinson's disease, Substantia nigra",

author = "Guoying Bing and Yi Zhang and Yoshifumi Watanabe and McEwen, {Bruce S.} and Stone, {Eric A.}",

note = "Funding Information: This work was partially supported by Grant MH 45265 and AFOSR F49620-92-J-0084.",

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doi = "10.1016/0006-8993(94)90534-7",

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T1 - Locus coeruleus lesions potentiate neurotoxic effects of MPTP in dopaminergic neurons of the substantia nigra

AU - Bing, Guoying

AU - Zhang, Yi

AU - Watanabe, Yoshifumi

AU - McEwen, Bruce S.

AU - Stone, Eric A.

N1 - Funding Information: This work was partially supported by Grant MH 45265 and AFOSR F49620-92-J-0084.

PY - 1994/12/30

Y1 - 1994/12/30

N2 - The observation that Parkinson's disease (PD) is associated with locus coeruleus (LC) noradrenergic neuronal degeneration suggests that the LC noradrenergic system may be involved in the pathogenesis and natural progression of the destruction of the substantia nigra (SN) dopaminergic neurons in Parkinson's disease. The relationship of these two systems was examined by injection of subtoxic doses of MPTP into unilateral LC 6-hydroxydopamine (6-OHDA) lesioned mice. A significant loss of dopaminergic cells was only found in the SN on the side of the LC lesions. These results suggest that the LC may have protective effects on SN dopaminergic neurons.

AB - The observation that Parkinson's disease (PD) is associated with locus coeruleus (LC) noradrenergic neuronal degeneration suggests that the LC noradrenergic system may be involved in the pathogenesis and natural progression of the destruction of the substantia nigra (SN) dopaminergic neurons in Parkinson's disease. The relationship of these two systems was examined by injection of subtoxic doses of MPTP into unilateral LC 6-hydroxydopamine (6-OHDA) lesioned mice. A significant loss of dopaminergic cells was only found in the SN on the side of the LC lesions. These results suggest that the LC may have protective effects on SN dopaminergic neurons.

KW - Dopamine

KW - Locus ceruleus

KW - MPTP

KW - Norepinephrine

KW - Parkinson's disease

KW - Substantia nigra

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Locus coeruleus lesions potentiate neurotoxic effects of MPTP in dopaminergic neurons of the substantia nigra

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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