Lone-term cognitive impact of anticholinergic medications in older adults

Kara A. Bottiggi, Juan C. Salazar, Lei Yu, Allison M. Caban-Holt, Melody Ryan, Marta S. Mendiondo, Frederick A. Schmitt

Research output: Contribution to journalArticlepeer-review

84 Scopus citations


Objective: The objective of this study was to determine whether chronic use of medications with anticholinergic (AC) properties impact older adults' cognitive functioning. Methods: Six years of cognitive test data from two groups of older adults (AC and control) were examined retrospectively (N = 592). Results: Declines over time were found for the AC group on parts A and B of the Trail Making Test. Conclusion: Physicians prescribing ACs to older adult patients should be aware of their potential effects on psychomotor speed and executive functioning. These cognitive effects may lead to impairments in daily functioning resulting in the need to reevaluate patient medications.

Original languageEnglish
Pages (from-to)980-984
Number of pages5
JournalAmerican Journal of Geriatric Psychiatry
Issue number11
StatePublished - Nov 2006


  • Anticholinergic
  • Cognition
  • Normal aging
  • Older adults

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health


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