Long-lasting physiological effects of bath applied N-methyl-d-aspartate

Olivier Thibault, Michel Joly, Dominique Muller, Frank Schottler, Serena Dudek, Gary Lynch

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


The present experiments describe a long-lasting form of potentiation induced in field CA1 of rat hippocampal slices by bath application of N-methyl-d-aspartate (NMDA), in association with low magnesium concentrations, glycine and spermine. The potentiation effect consisted of a 50% increase in slope of field potentials and was stable for at least 80 min post treatment. It was not accompanied by detectable changes in antidromic responses and was completely blocked by an antagonist of NMDA receptor. The possible relationship of pharmacologically induced potentiation to long-term potentiation (LTP) is discussed.

Original languageEnglish
Pages (from-to)170-173
Number of pages4
JournalBrain Research
Issue number1
StatePublished - Jan 2 1989

Bibliographical note

Copyright 2014 Elsevier B.V., All rights reserved.


  • 2-Amino-5-phosphonovalerate
  • Glycine
  • Long-term potentiation
  • N-Methyl-d-aspartate
  • Spermine

ASJC Scopus subject areas

  • Neuroscience (all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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