Long-lasting physiological effects of bath applied N-methyl-d-aspartate

Olivier Thibault; Michel Joly; Dominique Muller; Frank Schottler; Serena Dudek; Gary Lynch

doi:10.1016/0006-8993(89)91553-9

Long-lasting physiological effects of bath applied N-methyl-d-aspartate

Olivier Thibault, Michel Joly, Dominique Muller, Frank Schottler, Serena Dudek, Gary Lynch

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

The present experiments describe a long-lasting form of potentiation induced in field CA1 of rat hippocampal slices by bath application of N-methyl-d-aspartate (NMDA), in association with low magnesium concentrations, glycine and spermine. The potentiation effect consisted of a 50% increase in slope of field potentials and was stable for at least 80 min post treatment. It was not accompanied by detectable changes in antidromic responses and was completely blocked by an antagonist of NMDA receptor. The possible relationship of pharmacologically induced potentiation to long-term potentiation (LTP) is discussed.

Original language	English
Pages (from-to)	170-173
Number of pages	4
Journal	Brain Research
Volume	476
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(89)91553-9
State	Published - Jan 2 1989

Bibliographical note

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

Keywords

2-Amino-5-phosphonovalerate
Glycine
Long-term potentiation
N-Methyl-d-aspartate
Spermine

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(89)91553-9

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abstract = "The present experiments describe a long-lasting form of potentiation induced in field CA1 of rat hippocampal slices by bath application of N-methyl-d-aspartate (NMDA), in association with low magnesium concentrations, glycine and spermine. The potentiation effect consisted of a 50% increase in slope of field potentials and was stable for at least 80 min post treatment. It was not accompanied by detectable changes in antidromic responses and was completely blocked by an antagonist of NMDA receptor. The possible relationship of pharmacologically induced potentiation to long-term potentiation (LTP) is discussed.",

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AU - Thibault, Olivier

AU - Joly, Michel

AU - Muller, Dominique

AU - Schottler, Frank

AU - Dudek, Serena

AU - Lynch, Gary

PY - 1989/1/2

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N2 - The present experiments describe a long-lasting form of potentiation induced in field CA1 of rat hippocampal slices by bath application of N-methyl-d-aspartate (NMDA), in association with low magnesium concentrations, glycine and spermine. The potentiation effect consisted of a 50% increase in slope of field potentials and was stable for at least 80 min post treatment. It was not accompanied by detectable changes in antidromic responses and was completely blocked by an antagonist of NMDA receptor. The possible relationship of pharmacologically induced potentiation to long-term potentiation (LTP) is discussed.

AB - The present experiments describe a long-lasting form of potentiation induced in field CA1 of rat hippocampal slices by bath application of N-methyl-d-aspartate (NMDA), in association with low magnesium concentrations, glycine and spermine. The potentiation effect consisted of a 50% increase in slope of field potentials and was stable for at least 80 min post treatment. It was not accompanied by detectable changes in antidromic responses and was completely blocked by an antagonist of NMDA receptor. The possible relationship of pharmacologically induced potentiation to long-term potentiation (LTP) is discussed.

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KW - N-Methyl-d-aspartate

KW - Spermine

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Long-lasting physiological effects of bath applied N-methyl-d-aspartate

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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