Long Noncoding RNAs in Substance Use Disorders

Changhai Tian, Guoku Hu

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Substance abuse (including illicit and prescription drugs) has become a significant public health and economic burden. Acute and chronic substance use often leads to a pathologic pattern of behaviors as well as physiologic manifestations, such as tolerance and withdrawal, collectively called substance use disorders (SUDs). Clinical and animal studies have demonstrated that SUDs are heritable in both humans and rodents. The exact molecular mechanism(s), however, is mostly unclear. Long noncoding RNAs (lncRNAs) have emerged as pivotal epigenetic regulators of gene expression in various human diseases, including SUDs. This chapter summarizes current findings and thoughts on the dysregulation as well as the role of lncRNAs in the context of the use of substances, such as morphine, cocaine, methamphetamine, alcohol, etc. The potential applications of lncRNAs in SUDs will also be discussed in this chapter.

Original languageEnglish
Title of host publicationRNA Technologies
Number of pages26
StatePublished - 2020

Publication series

NameRNA Technologies
ISSN (Print)2197-9731
ISSN (Electronic)2197-9758

Bibliographical note

Publisher Copyright:
© 2020, Springer Nature Switzerland AG.


  • Alcohol
  • Cocaine
  • Fentanyl
  • Long noncoding RNAs
  • Marijuana
  • Methamphetamine
  • Morphine
  • Opioids
  • Substance use disorders
  • Tobacco/nicotine

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Biochemistry, medical
  • Cancer Research


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