Long-term clinical response to treatment and maintenance of localized aggressive periodontitis: a cohort study

Karina A.F.S. Miller, Luciana S. Branco-de-Almeida, Sandra Wolf, Nicole Hovencamp, Tina Treloar, Peter Harrison, Ikramuddin Aukhil, Yan Gong, Luciana M. Shaddox

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Aim: To evaluate long-term clinical response to periodontal therapy and maintenance in localized aggressive periodontitis (LAP). Materials and Methods: One hundred forty-one African Americans diagnosed with LAP, aged 5–25 years, were enrolled. Patients underwent periodontal mechanical debridement plus 1 week of amoxicillin/metronidazole. Mechanical therapy was repeated as needed and clinical parameters were recorded at baseline, 3, 6, 12, 18 and 24 months, and two additional annual follow-up visits after treatment. Radiographs from primary dentition of patients with LAP in permanent dentition, and additional healthy siblings (HS) were analysed retrospectively. Results: Periodontal therapy significantly improved probing depth and clinical attachment level up to 4 years (mean reductions: 2.18 ± 1.03 and 2.80 ± 1.43 mm, respectively). Percentage of affected sites was reduced at all time points and maintained up to 4 years. Non-compliance with antibiotics/appointments negatively affected the treatment response. Ninety per cent of LAP patients in permanent dentition and 32% of HS presented radiographic bone loss in primary dentition. Conclusions: Mechanical debridement with 1 week of systemic antibiotics along with proper periodontal maintenance was effective in the treatment and successful maintenance of LAP for up to 4 years. LAP in permanent dentition may be preceded in the primary dentition. Clinicaltrials.gov #NCT01330719.

Original languageEnglish
Pages (from-to)158-168
Number of pages11
JournalJournal of Clinical Periodontology
Issue number2
StatePublished - Feb 1 2017

Bibliographical note

Publisher Copyright:
© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd


  • aggressive periodontitis
  • antibiotics
  • dental scaling
  • long-term effects
  • maintenance
  • patient compliance
  • root planing
  • therapy

ASJC Scopus subject areas

  • Periodontics


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