Aim: To evaluate long-term clinical response to periodontal therapy and maintenance in localized aggressive periodontitis (LAP). Materials and Methods: One hundred forty-one African Americans diagnosed with LAP, aged 5–25 years, were enrolled. Patients underwent periodontal mechanical debridement plus 1 week of amoxicillin/metronidazole. Mechanical therapy was repeated as needed and clinical parameters were recorded at baseline, 3, 6, 12, 18 and 24 months, and two additional annual follow-up visits after treatment. Radiographs from primary dentition of patients with LAP in permanent dentition, and additional healthy siblings (HS) were analysed retrospectively. Results: Periodontal therapy significantly improved probing depth and clinical attachment level up to 4 years (mean reductions: 2.18 ± 1.03 and 2.80 ± 1.43 mm, respectively). Percentage of affected sites was reduced at all time points and maintained up to 4 years. Non-compliance with antibiotics/appointments negatively affected the treatment response. Ninety per cent of LAP patients in permanent dentition and 32% of HS presented radiographic bone loss in primary dentition. Conclusions: Mechanical debridement with 1 week of systemic antibiotics along with proper periodontal maintenance was effective in the treatment and successful maintenance of LAP for up to 4 years. LAP in permanent dentition may be preceded in the primary dentition. Clinicaltrials.gov #NCT01330719.
|Number of pages||11|
|Journal||Journal of Clinical Periodontology|
|State||Published - Feb 1 2017|
Bibliographical noteFunding Information:
The authors thank the dentists (Drs. Edward Zapert, John Bidwell, Dan Cober and Phillis Varnado) and all the staff from the health departments of Leon and Duval Counties, Florida. This study was supported by the National Institute of Dental and Craniofacial Research (NIH/NIDCR; grants #R01DE019456; #R90DE22 530-4).
© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
- aggressive periodontitis
- dental scaling
- long-term effects
- patient compliance
- root planing
ASJC Scopus subject areas