Long-term enhancement of K+-evoked release of l-glutamate in entorhinal kindled rats

Changiz Geula, Patrick A. Jarvie, Thomas C. Logan, John T. Slevin

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

Kainic acid- and K+-evoked in vitro release of endogenous amino acids from hippocampal slices were measured in rats kindled by entorhinal electrical stimulation. One month after completion of kindling, K+-evoked release of glutamate from hippocampal slices ipsilateral to the stimulus site was consistently greater than from both the contralateral hippocampus from kindled animals and all hippocampi of electroshock and sham-surgery control groups. Enhanced hippocampal neurotransmitter glutamate release may be involved in the permanent effects of electrical kindling.

Original languageEnglish
Pages (from-to)368-372
Number of pages5
JournalBrain Research
Volume442
Issue number2
DOIs
StatePublished - Mar 1 1988

Bibliographical note

Funding Information:
The authors thank Lindley P. Wemmer and Ramona M. Alcala for their expert technical assistance and Renee Eikins for typing the manuscript. This research was supported by the Veterans Administration Research Service, the NIA (1 T32 AG00084-01A1), and the Bertha LeBus Educational and Cha-litable Trust. J.T.S. is the recipient of a Teacher-ln-vestigator Development Award (NS00732) from the NINCDS.

Keywords

  • Amino acid
  • Glutamate
  • Hippocampus
  • Kainic acid
  • Kindling
  • Neurotransmitter release

ASJC Scopus subject areas

  • Neuroscience (all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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