Long term outcomes of patients transplanted for hepatocellular carcinoma with human immunodeficiency virus infection

P. Eman, Eduardo Chacon, M. Gupta, Jonathan C. Berger, Malay B. Shah, Hanine E. El Haddad, Amr El-Husseini, Anna C. Dela Cruz, Alla Grigorian, Xiaonan Mei, Roberto Gedaly

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: We aimed to study outcomes in HIV + patients with HCC in the US following Liver Transplantation (LT) using the UNOS dataset. Methods: The database was queried from 2003 to 2016 for patients undergoing LT with HCC, HIV+, and HCC/HIV+. Results: Out of 17,397 LT performed for HCC during the study period, 113 were transplanted for HCC with HIV infection (91 isolated livers). Patients transplanted for HCC/HIV+ were younger (55.54 ± 5.89 vs 58.80 ± 7.37, p < 0.001), had lower total bilirubin (1.20 vs 1.60, p = 0.042) significantly lower BMI (25.35 ± 4.43 vs 28.39 ± 5.17, p < 0.001) and were more likely to be co-infected with HBV (25.3% vs 8.2% p < 0.001) than those transplanted for HCC alone. HCC/HIV + patients were found to have a 3.8 fold increased risk of peri-operative mortality at 90 days after matching. HCC/HIV + recipients had 54% decreased long-term survival within the HCC cohort. Our initial analysis of overall graft and patient survival found significant differences between HCC/HIV– and HCC/HIV + recipients. However, these variances were lost after case-matching. Recurrence and disease free survival were similar in HCC alone vs HCC/HIV + recipients. Conclusions: Our analysis suggests that excellent outcomes can be achieved in selected patients with HCC/HIV+.

Original languageEnglish
Pages (from-to)1009-1016
Number of pages8
JournalHPB
Volume21
Issue number8
DOIs
StatePublished - Aug 2019

Bibliographical note

Publisher Copyright:
© 2019 International Hepato-Pancreato-Biliary Association Inc.

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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